出 处:《海南医学院学报》2019年第7期534-537,542,共5页Journal of Hainan Medical University
基 金:江苏省中医药管理局课题基金(YB2015122)~~
摘 要:目的:探讨红花黄色素联合脑苷肌肽治疗对缺血性脑卒中患者神经功能的影响,并分析其可能的机制。方法:选择2017年5月~2018年8月我院收治的缺血性脑卒中患者130例,依据随机数表法分为对照组和研究组各65例。对照组采用脑苷肌肽治疗,研究组在对照组的基础上应用红花黄色素治疗,比较两组患者治疗前后神经功能指标、氧化应激指标、血管内皮功能指标及炎症因子的变化。结果:两组患者治疗前神经功能指标、氧化应激指标、血管内皮功能指标及炎症因子比较,差异不显著(P>0.05)。治疗后,两组患者神经功能指标S-100β和NSE均显著降低,NGF水平显著升高,且研究组患者S-100β和NSE水平分别为(0.91±0.10)ng/L和(12.91±1.33)ng/L,显著低于对照组,NGF水平为(79.52±8.07)μg/L,显著高于对照组(P<0.05)。两组患者治疗后Ox-LDL水平显著降低,GSH-Px水平显著升高,且研究患者氧化应激指标Ox-LDL水平为(563.51±57.10)μg/dL,显著低于对照组,GSH-Px水平为(154.55±16.07)U/L,均显著高于对照组(P<0.05)。两组患者治疗后血管内皮功能指标NT-proBNP、TXB2及ET-1水平显著降低,研究组患者NT-proBNP、TXB2及ET-1分别为(95.91±9.77)pg/mL、(245.69±25.06)pg/mL及(64.26±6.65)ng/L,均显著低于对照组(P<0.05)。两组患者治疗后炎症因子MMP-9及TNF-α水平显著降低,且研究组患者MMP-9及TNF-α水平分别为(60.64±6.12)ng/mL及(0.33±0.04)ng/mL,均显著低于对照组(P<0.05)。结论:红花黄色素联合脑苷肌肽治疗缺血性脑卒中临床疗效较高,可显著改善患者的神经功能,其机制可能与改善血管内皮功能与应激反应有关。Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients with ischemic stroke admitted to my hospital from May 2017 to August 2018were enrolled. The patients were divided into the control group and the study group according to the random number table method, 65 cases in each group.The control group was treated with cerebroside carnosine.And the study group was treated with safflower yellow pigment on the basis of the control group. The changes of neurological function index, oxidative stress index, vascular endothelial function index and inflammatory factor were compared before and after treatment. Results: There were no significant differences in preoperative neurological parameters, oxidative stress, vascular endothelial function and inflammatory factors between the two groups ( P >0.05). After treatment, the neurological function indexes S-100β and NSE were significantly lower in both groups, and NGF levels were significantly increased. The S-100β and NSE levels in the study group were (0.91±0.10) ng/L and (12.91±1.33) ng/L, respectively, which were significantly lower than control group. While the NGF level of the study group was (79.52±8.07)μg/L significantly higher than that of the control group (both P <0.05). The levels of Ox-LDL were significantly reduced and GSH-Px levels were significantly elevated in both groups after treatment.The level of oxidative stress index Ox-LDL was (563.51±57.10)μg/dL, which was significantly lower than that of the control group, and the GSH-Px level was (154.55±16.07) U/L, which was significantly higher than the control group ( P <0.05). The levels of vascular endothelial function NT-proBNP, TXB2 and ET-1 were significantly lower in the two groups after treatment.The NT-proBNP, TXB2 and ET-1 in the study group were (95.91±9.77) pg/mL,(245.69±25.06) pg/mL and (64.26±6.65) ng/L, respectively, which were sig
关 键 词:红花黄色素 脑苷肌肽 神经功能 缺血性脑卒中 机制
分 类 号:R743.3[医药卫生—神经病学与精神病学]
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