母亲感染人类免疫缺陷病毒婴幼儿出生体格发育及免疫功能分析  

Analysis of immunity function of infants delivered by human immunodeficiency virus infected mothers

作　　者：韦秋芬[1] 潘新年[1] 阮毅燕[2] 丘小霞[3] 孙佩珠 郭小芳[1] 余尚阳 Wei Qiufen;Pan Xinnian;Ruan Yiyan;Qiu Xiaoxia;Sun Peizhu;Guo Xiaofang;She Shangyang(Department of Neonatology, Guangxi Maternal and Child Health Hospital, Nanning 530003, China;Department of Neurology, Guangxi Maternal and Child Health Hospital, Nanning 530003, China;Department of Obstetrics and Gynecology, Guangxi Maternal and Child Health Hospital, Nanning 530003, China;Clinical Laboratory, Guangxi Maternal and Child Health Hospital, Nanning 530003, China)

机构地区：[1]广西壮族自治区妇幼保健院新阳院区新生儿科,南宁530003 [2]广西壮族自治区妇幼保健院神经内科,南宁530003 [3]广西壮族自治区妇幼保健院妇产科,南宁530003 [4]广西壮族自治区妇幼保健院检验科,南宁530003

出　　处：《中华实用儿科临床杂志》2019年第5期364-367,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：广西医疗卫生适宜技术研究与开发课题(S201309-01);广西壮族自治区卫生厅重点课题(重2012022).

摘　　要：目的探讨人类免疫缺陷病毒(HIV)感染母亲所生非HIV感染婴幼儿出生时的体格发育及免疫功能。方法选择2008年1月至2011年11月广西地区297例HIV感染母亲所生婴幼儿为研究对象(观察组),研究对象根据是否HIV感染进一步分为HIV感染组和非HIV感染组,非HIV感染儿童根据母亲孕期是否使用抗反转录病毒药物(ART)治疗分为ART治疗组和非ART治疗组,选择91例同期出生的健康儿童为健康对照组,受试儿童均进行体格检查及T淋巴细胞亚群分析和体液免疫功能检测。结果观察组婴幼儿出生体质量、身高均低于健康对照组[(2.86±0.49) kg比(3.15±0.52) g/L;(47.05± 2.20) cm比(50.01±2.58) cm],差异均有统计学意义(t=2.652、2.247,均P<0.05);观察组婴幼儿CD8水平、CD4/CD8比值与健康对照组比较[(21.31±6.49)%比(22.01±5.43)%;1.82±0.79比1.82±0.67]差异均无统计学意义(t=0.933、0.033,均P>0.05);但CD3及CD4水平低于健康对照组儿童[(62.36±7.94)%比(65.70±6.32)%;(34.83±7.62)%比(37.02±5.69)%],差异均有统计学意义(t=3.66、2.946,均P<0.01);免疫球蛋白(Ig)M、IgG、IgA水平与健康对照组相比[(1.79±0.66) g/L比(1.76±0.66) g/L;(8.96±2.74) g/L比(8.80±1.97) g/L;(0.85±0.57) g/L比(0.86±0.41) g/L]差异均无统计学意义(t=0.341、0.619、0.173,均P>0.05)。观察组非HIV感染儿童的出生体质量、出生身高均低于健康对照组儿童[(2.92±0.43) kg比(3.15±0.52) kg;(49.03±2.22) cm比(50.01±2.58) cm],差异均有统计学意义(F=4.163、2.87,均P<0.05),且孕期使用ART治疗的母亲所生儿童的出生体质量、出生身高、出生头围均低于健康对照组儿童[(2.90±0.43) kg比(3.15±0.52) kg;(48.27±1.89) cm比(50.01±2.58) cm;(31.8±1.47) cm比(34.88±3.21) cm],差异均有统计学意义(F=3.711、2.970、3.689,均P<0.05)。观察组非HIV感染儿童的CD8水平、CD4/CD8比值与健康对照组儿童相比[(20.77±5.60)%比(22.01±5.43)%;(1.85±0.76)比(1.82±0.67)]差异均无统计学意义(Objective To explore the physical development and immune function of infants without human immunodeficiency virus(HIV) infection who were delivered by HIV-infected mothers. Methods Two hundred and ninety-seven infants delivered HIV-infected mothers in Guangxi province from January 2008 to November 2011 were selected as observation group.According to whether infants had HIV infection or not, the children were further divided into the HIV-infection group and the infants in the non-HIV infection group according to the presence or absence of HIV infection, and the infants in the non-HIV infection group were divided into the antiretroviral drug (ART) treatment group and the non-ART treatment group according to whether the mother had used ART during pregnancy.Ninety-one healthy children born at the same time were selected as the healthy control group.The physical examination, T lymphocyte subgroup analysis and humoral immunity test were performed on all infants. Results The weight and body length at birth of infants born from HIV-infected mothers were all significantly lower than those in the healthy control group [(2.86±0.49) kg vs.(3.15±0.52) kg;(47.05±2.20) cm vs.(50.01±2.58) cm], and the differences were statistically significant (t=2.652, 2.247, all P<0.05). The CD8 level and CD4/CD8 ratio of infants delivered by HIV-infected mothers had no significant differences statistically compared with those in the healthy control group[(21.31±6.49)% vs.(22.01±5.43)%;1.82±0.79 vs.1.82±0.67, t=0.933, 0.033, all P>0.05];the CD3 and CD4 levels were lower than those in the healthy control group[(62.36±7.94)% vs.(65.70±6.32)%;(4.83±7.62)% vs.(37.02±5.69)%], and the differences were statistically significant(t=3.66, 2.946, all P<0.01). The immunoglobulin(Ig)M, IgG and IgA levels of children born to HIV-infected mothers had no statistically significant differences compared with those in the healthy control group[(1.79±0.66) g/L vs.(1.76±0.66) g/L;(8.96±2.74) g/L vs.(8.80±1.97) g/L;(0.85±0.57) g/L vs.(0.86±0.41) g/

关 键 词：获得性免疫缺陷综合征 淋巴细胞亚群 体液免疫 儿童 

分 类 号：R725.1[医药卫生—儿科]