1-磷酸鞘氨醇在缺血性卒中中的作用:潜在的神经保护治疗靶点  

Roles of sphingosine 1-phosphate in ischemic stroke:a potential therapeutic target for neuroprotection

作　　者：曹渊博 刘佳[1] 朱慧 刘燕[1] 王雪[1] 贾添韧 檀国军[1] Cao Yuanbo;Liu Jia;Zhu Hui;Liu Yan;Wang Xue;Jia Tianren;Tan Guojun(Department of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 05000,China)

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000

出　　处：《国际脑血管病杂志》2019年第1期50-56,共7页International Journal of Cerebrovascular Diseases

摘　　要：缺血性卒中是导致人类死亡和残疾的重要原因之一,但目前治疗卒中后脑损伤的有效方法相当有限。1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种多效脂质,其代谢及调节与脑缺血后重要生物学事件相关的分子机制之间具有一定的相互依存关系。以S1P为核心的膜质疗法可能是有效的缺血性卒中神经保护策略。Ischemic stroke is one of the most important causes of death and disability in humans,but the effective methods for treating brain injury after stroke are quite limited.Sphingosine 1-phosphate(S1P)is a pleiotropic lipid.There is certain interdependence between its metabolism and regulation and the molecular mechanisms involved in important biological events following cerebral ischemia.Membrane lipid therapy with S1P as the core may be an effective neuroprotective strategy of ischemic stroke.

关 键 词：卒中 脑缺血 鞘氨醇 受体 溶血鞘磷脂 1-磷酸鞘氨醇 鞘氨醇激酶 炎症 盐酸芬戈莫德 神经保护药 

分 类 号：R743.3[医药卫生—神经病学与精神病学]