乳腺癌放疗增敏与机制研究进展  

Research progress on radiosensitization and mechanism in breast cancer

作　　者：张金花 杨碎胜[5] 司婧[1,3,4] ZHANGJin-hua;YANG Sui-sheng;SI Jing(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730030,P.R.China;College of Life Science ,University of Chinese Academy of Sciences ,Beijing 101408,P.R.China;CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine ,Institute of Modern Physical,Lanzhou 730030,P.R.China;Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province ,Institute of Modern Physical ,Lanzhou 730030,P.R.China;Department of Galactophore Gansu Provincial Cancer Hospital,Lanzhou 730030,P.R.China)

机构地区：[1]中国科学院近代物理研究所,甘肃兰州730030 [2]中国科学院大学生命科学学院,北京101408 [3]中国科学院重离子辐射生物医学重点实验室.近代物理研究所,甘肃兰州730030 [4]甘肃省重离子束辐射医学应用基础重点实验室.近代物理研究所,甘肃兰州730030 [5]甘肃省肿瘤医院乳腺科,甘肃兰州730030

出　　处：《中华肿瘤防治杂志》2019年第4期277-284,共8页Chinese Journal of Cancer Prevention and Treatment

基　　金：科技部国家重点研发项目(2016YFC0904600);国家自然科学基金联合基金重点项目(U1432248)

摘　　要：目的乳腺癌是女性最常见的恶性肿瘤之一,放射疗法是本病一种重要治疗方式,其实际疗效与肿瘤细胞放射敏感性密切相关。本研究介绍影响乳腺癌放疗敏感性的机制,并对乳腺癌放疗增敏剂或靶点及其相关作用机制的重要进展进行综述。方法应用PubMed、中国科学院文献情报中心及CNKI期刊全文检索系统,以"乳腺癌、放疗、端粒、端粒酶、放疗敏感性"为关键词,检索2008-2018相关文献。纳入标准:(1)乳腺癌放疗增敏/放疗抵抗;(2)研究结果中包含端粒、端粒酶与乳腺癌细胞放疗敏感性的关系。排除标准:(1)与乳腺癌放疗敏感性不相关;(2)机制阐述模糊。符合纳入排除标准的文献60篇。结果在影响乳腺癌放疗敏感性的众多因素中,端粒/端粒酶、纳米颗粒、miRNAs、乏氧、葡萄糖转运蛋白1、肿瘤干细胞和上皮-间充质转化过程等与辐射敏感性关系密切,可能是增强放疗对乳腺癌细胞影响的潜在靶点。可针对以上各项制定新的抗放射性肿瘤治疗策略和方式,提高疗效。结论放射治疗主要通过射线诱导细胞凋亡和坏死,并杀伤肿瘤细胞,后期可以把开发高效的放疗增敏药物和治疗方式作为研究重点,为放疗在乳腺癌及相关疾病中的有效应用提供理论依据。OBJ ECTIVE Breast cancer is one of the most prevalent malignancies among women. Radiotherapy is a powerful tool in the fight against breast cancer,while its therapeutic efficacy is closely dependent on the tumor sensitivity to radiation. This paper briefly introduces the mechanism that affects the radiosensitivity of breast cancer and summarizes the recent advances in radiosensitivity related molecular targets and radiosensitizer of mammary cancer. METHODS PubMed, National Science Library,Chinese Academy of Sciences and CNKI have been employed to search for related literature published between 2008-2018 using terms of breast cancer, radiotherapy, telomere, telomerase and radiosensitivity. The inclusion criteria:(1) radioresistance or radiosensitization of breast cancer;(2) the aim of the paper is to discuss the relationships between telomere, telomerase and radiosensitivity of breast cancer. Exclusion criteria:( 1 ) radiosensitivity unrelated to breast cancer;(2) The explanation of Mechanism is fuzzy. A total of 60 articles were enrolled according to the criteria. RESULTS Among the many factors affecting the sensitivity of breast cancer radiotherapy, telomere, telomerase, nanoparticles ,miRNAs, hypoxia, glucose transporter protein 1, cancer stem cells and epithelial-mesenchymal transition processes are closely related to radiation sensitivity, which may be a potential target for enhancing the effects of radiation therapy on breast cancer cells. New therapeutic strategies and methods to anti-radiation tumor should be developed to improve the curative effect. CONCLUSIONS Radiotherapy contributes to killing cancer cells through inducing cell apoptosis and necrosis. It is necessary for researchers to focus on the development of efficient radiosensitizer to provide a theoretical basis for studying the application of radiotherapy in the treatment of diseases.

关 键 词：乳腺癌 放射治疗 端粒/端粒酶 放疗增敏机制 放疗增敏剂 综述文献 

分 类 号：R737.9[医药卫生—肿瘤]