三阴性浸润性乳腺导管癌不同年龄组腋窝淋巴结转移情况及预后分析  

Axillary lymph node metastasis and prognosis of triple-negative invasive ductal breast cancer patients in different age groups

作　　者：敖冬歌 尹洪磊 赵斌 Ao Dongge;Yin Honglei;Zhao Bin(The Hospital Affiliated to Chifeng Collage,Chifeng 024000,China)

机构地区：[1]内蒙古赤峰市赤峰学院附属医院,024000

出　　处：《中华内分泌外科杂志》2019年第1期59-62,共4页Chinese Journal of Endocrine Surgery

摘　　要：目的探讨不同年龄分组的三阴性浸润性乳腺导管癌淋巴结转移情况及对患者预后的影响。方法选定本院从2008年1月1日至2017年12月31日的321例受体情况三阴性且诊断为浸润性乳腺导管癌的女性患者,所有患者均行正规手术治疗和术后放化疗。根据年龄分为3组:青年组(<40岁)、中年组(40~60岁)、老年组(≥60岁),比较3组腋窝淋巴结转移情况,术后1~5年无瘤存活率和预后因素。结果321例患者青、中、老年组分别为94、151、76例。腋窝淋巴结转移率老年组最低11.8%,中年组最高17.2%,青年组居中13.8%。患者随访1~5年,青、中、老年组复发转移率分别为56.4%、53.6%、17.1%,组间差异有统计学意义(P<0.05)。结论①三阴性乳腺癌患者在青年和老年组的淋巴结转移频率较低,在中年组具有相对较高的淋巴结转移频率;②青年组具有较高的复发转移率,预后相对较差,老年组的复发转移率最低,预后相对较好;③三阴性乳腺癌患者的预后可能和代谢相关;④三阴性乳腺癌患者更易发生血性转移,早期的辅助性全身治疗可能比局部放疗和早期的腋窝清扫对年轻的三阴性乳腺癌患者更有益。Objective To investigate the metastasis and the prognosis of the axillary lymph nodes in triple-negative and invasive ductal breast cancer patients of different ages.Methods 321 female breast cancer patients diagnosed as triple-negative and invasive ductal carcinoma from Jan.1,2008 to Dec.31,2017 were selected as the samples,all of whom were treated with regular surgical treatment and postoperative radiotherapy and chemotherapy,and were divided into three groups according to their ages,including the younger group(<40 years old),the middle age group(40 to 60 years old),and the elder group(≥60 years).We compared the metastasis of axillary lymph node,the disease-free survival rate after 1 to 5 years of the operations and the prognostic factors of the three groups.Results Among the 321 patients,there were 94 young patients,151 middle-aged patients and 76 elder patients.Among the three groups,the rate of axillary lymph nodes metastasis was the lowest in the elderly group(11.8%),the highest in the middle-aged group(17.2%)and middle in the young group(13.8%).The patients were followed up for 1 to 5 years.The recurrence rate of the young,middle-aged and elder groups was 56.4%,53.6% and 17.1% respectively.There was a significant difference between the three groups(P<0.05).Conclusion ①he frequency of LN transfer in patients of TNBC is lower in the younger and the elder patients than in the middle-aged patients.② The younger patients of TNBC have a higher recurrence rate and poor prognosis,while the elder patients of TNBC have the lowest recurrence rate and good prognosis.③The prognosis of TNBC may be related to metabolism,which,of course,needs to be further verified with the proof of blood and cell test.④The younger patients of TNBC are more likely to suffer blood metastasis,and adjuvant systemic therapy in early period may be more beneficial than local radiotherapy and early axillary dissection.

关 键 词：三阴性乳腺癌 腋窝淋巴结 血行播散 

分 类 号：R737.9[医药卫生—肿瘤]