四逆散有效组分拮抗空瓶刺激所致大鼠慢性情绪应激的作用  

The reversal effects of Sinisan active ingredients on rat's chronic emotional stress induced by empty bottles

作　　者：黄莉莉[1] 耿一玄 许庆瑞 李廷利[1] HUANG Lili;GENG Yixuan;XU Qingmi;LI Tingli(Pharmaceutical College, Heilongjiang University of Chinese Medicine, Harbin , 150040)

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《中国药物依赖性杂志》2019年第1期20-23,共4页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(81274114)

摘　　要：目的:探讨四逆散有效组分拮抗慢性情绪应激大鼠的作用。方法:利用连续21 d空瓶刺激所致大鼠慢性情绪应激模型,观察四逆散有效组分(450 mg/kg/day,连续21 d)对模型大鼠的体重、行为学、血清皮质酮含量及大鼠海马组织病变的影响。结果:四逆散有效组分能够有效拮抗空瓶刺激诱导的大鼠慢性情绪应激反应,表现为大鼠体重明显升高、攻击和探究行为减少、修饰行为增加、皮质酮含量降低、改善情绪应激导致的海马损伤。结论:四逆散有效组分可能是通过抑制皮质酮的含量升高,减少海马损伤而发挥其拮抗慢性情绪应激的作用。Objective: To explore the reversal effects of Sinisan active ingredients on chronic emotional stress in rats.Methods: The rats received empty bottle stimulation for 21 days in order to make chronic emotional stress. The modeled rats received Sinisan active ingredients treatment( 450 mg/kg/day,i. g.)or saline in the same volume for 21 days,respectively. The changing of body weight,behavioristics,concentration of serum corticosterone and central hippocampus neuronal tissue in model rats were measured as the main indexes.Results: Sinisan active ingredients had protective effect on rat’s chronic emotional stress induced by empty bottles,and the effect was characterized by enhancement of the body weight gain,reduction of aggressive and exploratory behaviors,increase of grooming behavior,reduced level of serum corticosterone, and development of hippocampus injuries.Conclusion: The results suggested that inhibition of the elevated corticosterone levels and reduction of the area of hippocampus injuries may play important roles in the reversal effects of active ingredients of Sinisan on chronic emotional stress.

关 键 词：四逆散有效组分 慢性情绪应激 空瓶刺激 血清皮质酮 

分 类 号：R749[医药卫生—神经病学与精神病学]