帕金森病轻度认知功能障碍的研究进展  

The research progress of mild cognitive impairment in Parkinson's disease

作　　者：张杉 陈涛[1] 邓益东[1] 刘艳慧[1] 滕思 蔡奔驰 苏佳丽 林杰[1] Zhang Shan;Chen Tao;Deng Yidong;Liu Yanhui;Teng Si;Cai Benchi;Su Jiali;Lin Jie(Department of Neurology, Hainan General Hospital, Haikou 570311, China)

机构地区：[1]海南省人民医院神经内科,海口570311

出　　处：《中国医师杂志》2019年第3期467-470,共4页Journal of Chinese Physician

基　　金：国家自然科学基金项目(81060096; 81560202);海南省重点科研课题项目(14A110060);海南省应用技术研发与示范推广专项项目(ZDXM2015067);海南省自然科学基金创新团队项目(2016CXTD010)~~

摘　　要：帕金森病(PD)是一种以黑质多巴胺能神经元变性、缺失和路易体形成为病理特征的神经退行性疾病,临床表现除运动症状外,还包括非运动症状。认知功能障碍(PD-CI)是帕金森病患者最常见的非运动症状之一。其分为轻度认知功能障碍(PD-MCI)和痴呆(PDD)。PD-MCI是帕金森病痴呆的早期表现,因此早期诊断和治疗PD-MCI对帕金森病的预后非常重要。本文就PD-MCI的流行病学、危险因素、遗传、生物学标志物、影像学、诊断及治疗作一综述。Parkinson's disease (PD) is a neurodegenerative disease characterized by degeneration and deletion of dopaminergic neurons in the substantia nigra and a pathological feature of the Louis body. The clinical manifestations including non motor symptoms and motor symptoms. Cognitive impairment (CI) is one of the most common non motor symptoms in patients with PD, Which includes mild cognitive impairment (MCI) and dementia. MCI is an early manifestation of dementia in PD. Therefore, early diagnosis and treatment of MCI are very important for the prognosis of PD. The epidemiology, risk factors, heredity, biomarkers, imaging, diagnosis and treatment of MCI in PD are reviewed in this paper.

关 键 词：帕金森病 认知障碍 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]