基于潜在类别分析方法对遗忘型轻度认知功能障碍证候规律的研究  

Study on Syndromes of Amnestic Mild Cognitive Impairment Based on Latent Class Analysis

作　　者：王金侠[1] 侯燕[1] 郑慧莉 张旭 张莞童 李晓丽 贾晓宁 陈民[1] WANG Jinxia;JIA Xiaoning;ZHENG Huili;ZHANG Xu;ZHANG Wantong;LI Xiaoli;CHEN Min(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032 , Liaoning, China;Graduate School of Liaoning University of Chinese Medicine, Shenyang 110847 , Liaoning, China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学研究生学院,辽宁沈阳110847

出　　处：《中华中医药学刊》2019年第3期661-664,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室项目(2013-1197);沈阳市科技局人口与健康科技攻关专项项目(F16-206-9-24)

摘　　要：目的:采用潜在类别分析(Latent Class Analysis,LCA)方法研究遗忘型轻度认知功能障碍(amnestic Mild Cognitive Impairment,aMCI)的证候规律。方法:采用调查问卷的方式,对沈阳市2家三级甲等性医院及6家养老中心进行筛查,经纳排标准筛选后纳入符合aMCI诊断标准的老年样本共300例。收集患者基本资料和临床症状学资料建立数据库,以频数分析方法研究患者在aMCI的症状分布情况,再通过潜在类别分析方法,得出aMCI核心的中医证候类型。结果:排在前15位的症状是:善忘、智能减退、反应迟钝、头晕、乏力、腰膝酸软、失算、神疲、尿频、大便干、胸闷、耳鸣、气短、心烦、口干。经LCA分析后,可根据专业知识将aMCI中医证型分为6个潜在的类别,肝肾不足证占34.33%、心脾两虚证占21.33%、痰浊蒙窍证占14.00%、肝郁气滞证占12.00%、脾肾阳虚证占11.33%、肾精不足证占7.00%。结论:aMCI涉及多脏腑的功能失调,以肝肾心脾为核心,痰浊、气郁为标,呈现出本虚标实的证候特征。Objective: To study the syndrome patterns of amnestic mild cognitive impairment ( aMCI) based on latent class analysis( LCA). Methods: A questionnaire was used to screen two tertiar:A hospitals and six old - age care centers in Shenyang. A total of 300 elderly patients who met the aMCI diagnostic criteiia were selected after screening. The database of patients5 basic data and clinical symptomatology data were collected. The frequency distribution analysis was used to study the distribution of patients' aMCI symptoms. Through the analysis of potential categories, the core types of aMCI syndromes were obtained. Results: The top 15 symptoms were forgetfulness, diminished intelligence, unresponsiveness, dizziness, fatigue, weak knees, miscalculation, fatigue, urinary frequency, dry stool, chest tightness, tinnitus, shortness of breath, upsetness, and dry mouth. After LCA analysis, the aMCI TCM syndromes can be divided into 6 potential categories according to their professional knowledge. Liver - kidney Yin deficiency syndrome accounted for 34. 33%, heart and spleen deficiency accounted for 21.33%, and phlegm phlegm syndrome accounted for 14. 00%. Yuqi stagnation accounted for 12. 00%, spleen and kidney Yang deficiency accounted for 11.33%, kidney essence deficiency accounted for 7. 00%. Conclusion: The aMCI is involved in the dysfunction of multiple organs, with the liver, kidneys and spleen as the core, phlegm and Qi depression as the targets, presenting the syndrome features of this virtual reality.

关 键 词：潜在类别分析方法 遗忘型轻度认知功能障碍 证候 

分 类 号：R749.1[医药卫生—神经病学与精神病学]