帕金森病早期患者的情绪记忆研究  

Emotional memory in patients with early-stage Parkinson′s disease

作　　者：唐向阳[1] 袁良津[1] 汪凯[2] 陈祚胜[1] Tang Xiangyang;Yuan Liangjin;Wang Kai;Chen Zuosheng(Department of Neurology,Anqing Municipal Hospital,Anqing,Anhui 246003,China;Department of Neurology,the First Affiliated Hospital,Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽省安庆市立医院神经内科,246003 [2]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《中华神经科杂志》2019年第3期184-189,共6页Chinese Journal of Neurology

摘　　要：目的探讨帕金森病早期患者情绪记忆的改变特征,为及早识别帕金森病早期认知功能改变和评估干预治疗前移提供理论依据。方法建立情绪记忆的神经认知试验方法和事件诱发电位检测方法,检测2016年6月至2018年6月于安徽省安庆市立医院神经内科就诊的30例未治疗帕金森病早期患者(帕金森病组)和同期教育水平等匹配的30名健康成年人(对照组)的情绪记忆。结果对照组对负性情绪图片再认正确率为55.83%±4.17%,帕金森病组为50.30%±4.04%,差异有统计学意义(t=4.85,P<0.05);且对照组P300潜伏期为(337.47±7.87)ms、波幅为(6.34±0.62)μV、反应时间为(3 729.21±226.85)ms,帕金森病组分别为(344.20±7.94)ms、(5.75±0.52)μV、(3 935.33±222.24)ms,差异均有统计学意义(t=-3.30、4.04、2.76,均P<0.05)。两组对正性和中性情绪图片再认正确率、反应时间及P300潜伏期、波幅差异均无统计学意义(均P>0.05)。帕金森病组对正性、中性和负性情绪图片再认正确率(分别为57.97%±4.44%、49.77%±4.49%、50.30%±4.04%)、反应时间[分别为(3 725.87±210.10)ms、(4 085.80±231.67)ms、(3 935.33±222.24)ms]、P300潜伏期[分别为(328.07±6.07)ms、(347.37±7.49)ms、(344.20±7.94)ms]和波幅[分别为(6.55±0.66)μV、(5.57±0.63)μV、(5.75±0.52)μV]差异均有统计学意义(F=39.17、9.58、60.32、22.44,均P<0.05),但中性与负性情绪图片再认正确率差异无统计学意义(P>0.05);而对照组也对正性、中性和负性图片再认正确率(分别为59.47%±4.61%、50.63%±4.96%、55.83%±4.17%)、反应时间[分别为(3 657.13±218.85)ms、(4 026.81±221.23)ms、(3 729.21±226.85)ms]、P300潜伏期[分别为(326.13±5.96)ms、(345.10±7.95)ms、(337.47±7.87)ms)]和波幅[分别为(6.69±0.68)μV、(5.59±0.67)μV、(6.34±0.62)μV]差异有统计学意义(F=25.85、8.57、51.04、22.15,均P<0.05)。两组对情绪图片效价评分差异均无统计学意义(均P>0.05);但对负性情绪图片效价�ObjectiveTo explore the characteristics of emotional memory in patients with early-stage Parkinson′s disease(PD).MethodsThe methods of emotional memory neuro-cognitive test and event-related evoked potentials(ERPs)test were set.The emotional memory was detected in 30 early-stage PD patients without treatment(PD group)and 30 matched(including education level,etc)healthy controls(control group),who were recruited in the Department of Neurology,Anqing Municipal Hospital from June 2016 to June 2018.ResultsCompared with the control group(55.83%±4.17%),the negative valence picture recognition rate in the PD group(50.30%±4.04%)showed statistically significant difference(t=4.85,P<0.05).The ERPs-P300 latency was(337.47±7.87)ms,the amplitude was(6.34±0.62)μV,and the reaction time was(3 729.21±226.85)ms in the control group,showing statistically significant difference(t=-3.30,4.04,2.76,P<0.05)compared with that in the PD group((344.20±7.94)ms,(5.75±0.52)μV,(3 935.33±222.24)ms,respectively).There was no statistically significant difference in positive and neutral stimuli recognition between the two groups(P>0.05).In the PD group,the correct recognition in positive,neutral and negative valence pictures(57.97%±4.44%,49.77%±4.49%,50.30%±4.04%,respectively)showed statistically significant difference(F=39.17,P<0.05),also seen in the reaction time((3 725.87±210.10)ms,(4 085.80±231.67)ms and(3 935.33±222.24)ms,respectively;F=9.58,P<0.05),P300 latency((328.07±6.07)ms,(347.37±7.49)ms and(344.20±7.94)ms,respectively;F=60.32,P<0.05),and amplitude((6.55±0.66)μV,(5.57±0.63)μV and(5.75±0.52)μV,respectively;F=22.44,P<0.05).But there was no statistically significant difference between negative and neutral stimuli recognition in the PD group(P>0.05).In the control group,the correct recognition in positive,neutral and negative valence pictures(59.47%±4.61%,50.63%±4.96%,55.83%±4.17%,respectively)also showed statistically significant difference(F=25.85,P<0.05),also seen in the reaction time((3 657.13±218.85)ms,(4

关 键 词：帕金森病 情绪 记忆 认知 事件诱发电位 P300 

分 类 号：R742.5[医药卫生—神经病学与精神病学]