神经病理性疼痛中神经生长因子的作用及其相关镇痛药物研发进展  

Research Advance in NGF in Neuropathic Pain and Related Drugs

作　　者：颜冰 戴文玲 刘吉华 YAN Bmg;DAI Wenling;LIU Jihua(Jiangsu Key Laboratoiy ofTCM Evaluation and Translational Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院江苏省中药评价与转化重点实验室,江苏南京211198

出　　处：《药学进展》2019年第2期111-117,共7页Progress in Pharmaceutical Sciences

基　　金：十二五重大新药创制专项(No.2012ZX09J12110-06B)

摘　　要：神经生长因子(NGF)是一种重要的致痛物质,可通过促进外周炎症反应、伤害感受器敏化、异位放电、交感神经芽生及中枢敏化参与神经病理性疼痛的发生和维持,NGF及其受体已成为临床镇痛药物开发的重要靶点。目前,已研发出多种NGF抗体及NGF与其受体的小分子抑制剂用于治疗神经病理性疼痛。综述NGF参与调节神经病理性疼痛的机制及调节NGF的镇痛药物研发进展,为靶向NGF治疗神经病理性疼痛的研究提供参考。As an important pronociceptive mediator,nerve growth factor(NGF)plays a key role in the generation and maintenance of neuropathic pain by promoting peripheral inflammation,nociceptor sensitization,ectopic discharge,sympathetic sprouting and central sensitization.NGF and its receptors have become important targets for developing drugs against various neuropathic pain conditions.Several,NGF antibodies and small-molecule inhibitors of NGF or the related receptors have been developed for the treatment of neuropathic pain.This review summarized the mechanisms of NGF’s involvement in neuropathic pain and the progress in the development of anti-NGF agents,so as to provide reference for neuropathic pain management by targeting NGF.

关 键 词：神经生长因子 神经病理性疼痛 抗体药物 小分子抑制剂 

分 类 号：R964[医药卫生—药理学]