铂类新辅助化疗联合同步放化疗治疗中晚期宫颈鳞癌的临床疗效分析  

Clinical value of platinum neoadjuvant chemotherapy combined with simultaneous radiotherapy and chemotherapy in the treatment of cervical squamous cell carcinoma in the middle and late stages

作　　者：张颖[1] 莫安薇[2] ZHANG Ying;MO Anwei(Department of Ursing, Hainan Provincial People′s Hospital, Haikou Hainan 570311, China;Department of Oncology, Hainan Provincial People′s Hospital, Haikou Hainan 570311, China)

机构地区：[1]海南省人民医院护理部,海南海口570311 [2]海南省人民医院肿瘤内科,海南海口570311

出　　处：《新疆医科大学学报》2019年第4期484-488,共5页Journal of Xinjiang Medical University

基　　金：海南省卫计卫科研项目(14A210223)

摘　　要：目的研究铂类新辅助化疗联合同步放化疗对中晚期宫颈鳞癌的治疗效果。方法选取2014年1月-2017年12月海南省人民医院肿瘤内科收治的符合纳入标准的中晚期宫颈鳞癌患者112例,分为常规组和对照组,常规组采用同步放化疗的方案治疗,对照组采用铂类新辅助化疗联合同步放化疗的方案治疗,观察2组患者的总有效率、病灶缩小率、肿瘤最大直径、分期变化和复发率的变化,运用重复测量方差分析观察2组患者肿瘤最大直径在治疗后3个月、1年、2年、3年的变化情况。随访3年,绘制Kaplan-Meier生存曲线分析2组患者的预后差异。结果 2组患者治疗后疗效评价、总有效率、病灶缩小率、肿瘤最大直径、分期变化较前明显改善(P均<0.05)。在治疗后3个月、1年、2年、3年,对照组在治疗后各时间点肿瘤最大直径显著低于常规组(P均<0.05);Kaplan-Meier生存曲线结果显示,对照组的治疗效果优于常规组(P均<0.05);对照组治疗后并发症发生率高于常规组(P均<0.05)。结论铂类新辅助化疗联合同步放化疗对中晚期宫颈鳞癌的治疗效果优于同步放化疗,但其治疗后并发症发生率高于同步放化疗。铂类新辅助化疗联合同步放化疗对宫颈鳞癌治疗的综合效果仍待进一步研究。Objective To explore the clinical value of platinum neoadjuvant chemotherapy combined with simultaneous radiotherapy and chemotherapy in the treatment of cervical squamous cell carcinoma in the middle and late stages. Methods 112 patients with advanced cervical squamous cell carcinoma who met the inclusion criteria in the Department of Oncology, Hainan Provincial People′s Hospital from January 2014 to December 2017 were selected and divided into the routine group and the control group. The regular group was treated with concurrent radiotherapy and chemotherapy and the control group was treated with platinum neoadjuvant chemotherapy combined with simultaneous radiotherapy and chemotherapy. The total effective rate, the rate of lesion, the maximum diameter of the tumor, the change of stage and recurrence rate of the two groups before and after treatment were observed. After 3 years follow-up, the difference of prognosis between the two groups was analyzed by Kaplan-Meier survival curve. Results The evaluation of curative effect after treatment in both groups showed that the total effective rate, lesion reduction rate, tumor maximum diameter and stage change were significantly improved compared with those before treatment(P<0.05). At 3 months, 1 year, 2 years, 3 years after treatment, the maximum diameter of tumor in the control group was significantly lower than that in the routine group at each time point after treatment(P<0.05). The results of Kaplan-Meier survival curve showed that the therapeutic effect of the control group was better than that of the routine group(P<0.05). The incidence of complications after treatment in the control group was significantly higher than that in the conventional group(P<0.05). Conclusion The comprehensive effect of platinum neoadjuvant chemotherapy combined with concurrent radiotherapy and chemotherapy on cervical squamous cell carcinoma remains to be further studied.

关 键 词：铂类 新辅助化疗 同步放化疗 宫颈鳞癌 

分 类 号：R737.33[医药卫生—肿瘤]