基质金属蛋白酶-2基因1306 C/T多态性与前列腺癌易感性关联的Meta分析  

Correlation between MMP2-1306 C/T Polymorphism and Prostate Cancer Susceptibility:A Meta-Analysis

作　　者：宋宇轩 郭嘉[1] 胡接平 陈庆科[3] 唐寒梅[4] 傅燕艳[4] 陈小龙[4] 胡旺[4] 黄鹏[4,5] SONG Yu-xuan;GUO Jia;HU Jie-ping;CHEN Qing-ke;TANG Han-mei;FU Yan-yan;Chen Xiao-long;HU Wang;HUANG Peng(Grade 2013 of the First Clinical Medical College Nanchang 330006,China;Department of Urology, the First Affiliated Hospital Nanchang 330006,China;Department of Epidemiology of School of Public Health,Nanchang University,Nanchang 330006,China;Department of Urology, Tianjin Medical University General Hospital,Tianjing 300052,China;Jiangxi Provincial Key Laboratory of Preventive Medicine,Nanchang 330006,China)

机构地区：[1]南昌大学第一临床医学院,2013级南昌330006 [2]天津医科大学总医院泌尿外科,天津300052 [3]南昌大学第一附属医院泌尿外科,南昌330006 [4]南昌大学公共卫生学院流行病学教研室,南昌330006 [5]江西省预防医学重点实验室,南昌330006

出　　处：《南昌大学学报（医学版）》2019年第1期23-29,共7页Journal of Nanchang University：Medical Sciences

摘　　要：目的系统评价基质金属蛋白酶-2基因(matrix metalloproteinase 2,MMP2)基因rs243865单核苷酸多态性与前列腺癌易感性的关联。方法检索PubMed、Embase、Medline以及中国知网、万方数据库和中国生物医学文献数据库,查找有关MMP2基因rs243865位点多态性与癌症易感性关联的病例对照研究,检索时限为建库至2018年4月1日。由2名研究者筛选文献、提取数据后,使用纽卡斯尔-渥太华量表(Newcastle-Ottawa scale,NOS)进行文献的质量评价。采用Stata 12.0软件进行Meta分析,通过敏感性分析考察结果的稳定性、亚组分析探讨异质性来源、Begg秩相关法评价发表偏倚。结果共纳入6篇文献,合计3909例研究对象,其中前列腺癌患者1921例,健康对照1988例。Meta分析结果显示,等位基因模型T vs. C(OR=1.105,95%CI:0.994～1.227)、隐性基因模型TT vs. CT+CC(OR=1.014,95%CI:0.781～1.315)和纯合子模型TT vs. CC(OR=1.086,95%CI:0.832～1.418)中,癌症易感性差异无统计学意义;显性基因模型TT+CT vs. CC(OR=1.157,95%CI:1.017～1.317)和杂合子模型TC vs. CC(OR=1.498,95%CI:1.078～2.080)中,癌症易感性差异有统计学意义。结论 MMP2基因rs243865多态性与前列腺癌易感性相关,其中C等位基因可能是保护因素,而T等位基因可能是前列腺癌的易感因素,TC基因型可能为前列腺癌患者的风险基因型。Objective To evaluate the relationship between matrix metalloproteinase 2(MMP2) rs243865 polymorphism and prostate cancer(PCa) susceptibility. Methods The case-control studies about the correlation between MMP2-1306 C/T polymorphism and PCa susceptibility were retrieved from PubMed,Medline,Embase,CNKI,CBM and Wanfang Data by two researchers.The retrieval time was from their establishment to April 1,2018.After the literature screening and data extraction,the Newcastle-Ottawa Scale(NOS) was used to evaluate the quality of studies.The meta-analysis was conducted using Stata 12.0 software.The stability of results was investigated by sensitivity analysis.The source of heterogeneity was explored by subgroup analysis.The publication bias was evaluated by Begg rank correlation test. Results A total of 6 case-control studies involving 1921 PCa patients and 1988 healthy controls were included.Meta-analysis showed that there was no significant difference in cancer susceptibility between allele model T and C( OR =1.105,95% CI :0.994-1.227),as well as between recessive gene model TT and CT+CC( OR =1.014,95% CI :0.781-1.315) and between homozygous model TT and CC( OR =1.086,95% CI :0.832-1.418).However,the difference was significant between dominant gene model TT+CT and CC( OR =1.157,95% CI :1.017-1.317) and between heterozygote model TC and CC( OR = 1.498,95% CI :1.078-2.080). Conclusion MMP2 rs243865 polymorphism was associated with PCa susceptibility.The C-allele may be a protective factor,while T-allele may be susceptible to PCa.TC genotype may be a risk genotype for PCa patients.

关 键 词：基质金属蛋白酶2基因 rs243865 单核苷酸多态性 前列腺癌 META分析 

分 类 号：R737.25[医药卫生—肿瘤] R394.3[医药卫生—临床医学]