低剂量芬太尼透皮贴对中重度癌痛患者的镇痛效果观察  

Observation on analgesic effect of low-dose transdermal fentanyl patch in patients with moderate to severe cancer pain

作　　者：谢科宇[1] 刘佳 凌华 谢先丰[1] Xie Keyu;Liu Jia;Ling Hua;Xie Xianfeng(Department of Anesthesiology,Chengdu Second People's Hospital,Chengdu,Sichuan,610007,China)

机构地区：[1]成都市第二人民医院麻醉科,成都610007

出　　处：《西南国防医药》2019年第4期415-417,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：四川省卫计委普及应用项目(18PJ164)

摘　　要：目的探讨低剂量芬太尼透皮贴(TDF)对中重度癌痛患者的镇痛效果及其不良反应。方法选择中、重度癌痛共68例患者,分为中度疼痛组(n=37)与重度疼痛组(n=31),两组均采用低剂量TDF(12.5μg/h)镇痛治疗,观察镇痛效果及患者不良反应发生情况。结果两组性别、年龄、肿瘤转移情况、既往治疗和肿瘤类型等一般资料比较无统计学差异(P <0.05);治疗后,两组疼痛NRS评分均明显下降(P <0.05);与中度疼痛组相比,重度疼痛组降低幅度更大(P <0.05);两组治疗期间不良反应发生率比较无明显差异(P> 0.05)。结论低剂量TDF是一种有效的控制中、重度癌症疼痛的治疗方式,且不良反应少。建议对于中重度癌症疼痛患者的镇痛治疗,以12.5μg/h作为TDF的起始剂量。Objective To explore the analgesic effect and adverse reactions of low-dose transdermal fentanyl(TDF)patch in patients with moderate to severe cancer pain.Methods A total of 68 patients with moderate to severe cancer pain were divided into a moderate pain group(n=37)and a severe pain group(n=31).Both groups were treated with low-dose TDF(12.5μg/h).The analgesic effect and the occurrence of adverse reactions were observed.Results There was no significant difference in gender,age,metastasis of tumors,past treatment and types of tumors between the two groups.After the treatment,the NRS scores of pain in both groups decreased significantly(P<0.05);compared with the moderate pain group,the severe pain group decreased more significantly(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05).Conclusion Low-dose TDF is an effective way to control moderate to severe cancer pain,with fewer adverse reactions.It is suggested that the initial dose of TDF should be 12.5μg/h for the analgesic treatment of moderate to severe cancer pain.

关 键 词：芬太尼 低剂量 透皮贴 癌痛 镇痛 效果 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]