外周血循环肿瘤细胞与膀胱癌患者临床特征、复发转移的关系  

Relationship between circulating tumor cells and the clinical characteristics,recurrence and metastasis of bladder cancer

作　　者：金一 李江松 李博 JIN Yi;LI Jiangsong;LI Bo(Department of Urologic Surgery,Liaocheng Hospital of Traditional Chinese Medicine,Liaocheng 252000,Shandong,China)

机构地区：[1]聊城市中医院泌尿外科,山东聊城2520000

出　　处：《癌症进展》2019年第7期847-850,共4页Oncology Progress

摘　　要：目的探讨外周血循环肿瘤细胞(CTC)与膀胱癌患者临床特征、术后复发转移的关系。方法术前采用CanPatrolTM法检测68例膀胱癌患者外周血CTC的分型,据此分为单纯间质型组(n=17)、单纯上皮型组(n=21)、混合型组(n=23)和未检出组(n=7),分析CTC的分型与膀胱癌患者临床特征的关系,膀胱癌患者术后1年复发转移的影响因素采用Logistic回归分析。结果单纯间质型组、单纯上皮型组、混合型组和未检出组膀胱癌患者术后中位无进展生存期(PFS)分别为12.6、15.7、14.6和17.8个月。单因素分析结果显示,不同病理分级、TNM分期、淋巴结转移情况、CTC分型、术后辅助化疗情况膀胱癌患者术后1年复发转移情况比较,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,单纯间质型CTC、TNM分期为Ⅲ期、有淋巴结转移、术后未接受辅助化疗和病理分级为Ⅲ级是膀胱癌患者术后1年发生复发转移的独立危险因素。结论不同外周血CTC分型可能与膀胱癌患者的病理分级、TNM分期、淋巴结转移情况有关,单纯间质型CTC、TNM分期为Ⅲ期、有淋巴结转移、术后未接受辅助化疗和病理分级为Ⅲ级是膀胱癌患者术后1年发生复发转移的独立危险因素。Objective To investigate the relationship between circulating tumor cell (CTC) and the clinical characteristics, recurrence and metastasis of bladder cancer.Method Peripheral blood CTC typing of 68 patients with bladder cancer was detected by CanPatrolTM method before operation.According to this,the patients were divided into simple interstitial type group (n=17),simple epithelial type group (n=21),mixed type group (n=23) and undetected group (n=7).The relationship between CTC subtypes and clinical characteristics of patients with bladder cancer was analyzed,besides,Logistic regression analysis was used to determine the factors influencing the recurrence and metastasis in patients with bladder cancer within 1 year after surgery.Result The median progress free survive (PFS) of bladder cancer patients with simple interstitial type group,simple epithelial type group,mixed type group,and undetected group were 12.6,15.7,14.6,and 17.8 months,respectively.Univariate analysis indicated that,pathological classification,TNM stage,lymph node metastasis, CTC subtypes,and postoperative adjuvant chemotherapy were associated with the recurrence and metastasis of bladder cancer patients within 1 year after surgery,demonstrating statistically significant differences (P<0.05).Logistic regression analysis showed that,simple interstitial type CTC,TNM stage of Ⅲ,presence of lymph node metastasis,no adjuvant chemotherapy after operation,and pathological classification of grade Ⅲ were independent risk factors for the recurrence and metastasis of bladder cancer patients within 1 year after surgery.Conclusion Different peripheral blood CTC subtypes are likely related to the pathological classification,TNM stage and lymph node metastasis of bladder cancer patients, besides,simple interstitial type CTC,TNM stage of Ⅲ,presence of lymph node metastasis,no adjuvant chemotherapy after surgery and pathological classification of grade Ⅲ were independent risk factors for recurrence and metastasis in bladder cancer patients within 1 year a

关 键 词：循环肿瘤细胞 膀胱癌 临床特征 复发 转移 

分 类 号：R737.14[医药卫生—肿瘤]