面部带状疱疹继发角膜损伤的危险因素分析  

An analysis on risk factors of secondary corneal injury in patients with facial herpes zoster

作　　者：蒋超然[1] 刘治强[2] JIANG Chao-ran;LIU Zhi-qiang(Department of Ophthalmology , Nanxishan Hospital of Guangxi Zhuang AutonomousRegion , Guilin , Guangxi 541002 , China)

机构地区：[1]广西壮族自治区南溪山医院眼科,广西桂林541002 [2]桂林医学院附属医院口腔科,广西桂林541001

出　　处：《实用医药杂志》2019年第4期298-300,303,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨面部带状疱疹继发角膜损伤的危险因素。方法选取2015年1月—2017年12月广西壮族自治区南溪山医院收治的166例面部带状疱疹患者,将其中发生角膜损伤患者45例作为病例组,无角膜损伤的患者121例作为对照组,采用病例对照研究方法对面部带状疱疹继发角膜损伤患者进行分析,先将研究变量做单因素分析,再将有意义的变量进行多因素非条件Logistic回归分析。结果单因素分析显示,年龄(≥60岁)、发生部位(三叉神经)、长期使用糖皮质激素、皮损分布(三叉神经)、后遗神经痛和眼部症状与面部带状疱疹继发角膜损伤显著相关(P<0.05);多因素Logistic回归分析,发生部位(三叉神经,OR=0.166)、长期使用免疫抑制剂(OR=2.773)、皮损分布(三叉神经,OR=0.771)和并发眼部症状(OR=3.313)与面部带状疱疹继发角膜损伤相关(P<0.05)。结论医师应关注面部带状疱疹继发角膜损伤的危险因素,早期给予积极治疗。Objective To explore the risk factors of secondary corneal injury in patients with facial herpes zoster. Methods A total of 166 patients with facial herpes zoster admitted in leader author's hospital from January 2015 to December 2017 were recruited in this study , among them 45 complicated with corneal injury were signed as case group , 121 without corneal injury as control group. The case-control study was conducted for the facial herpes zoster patients with secondary corneal injury. Univariate analysis was firstly performed on the study variables and multivariate logistic regression analysis was then performed on the meaningful variables. Results The univariate analysis showed the age ( more than 60 yr ), location ( trigeminal nerve ), long -term use of immunosuppressive agents , distribution of skin lesions ( trigeminal nerve ), complicated with neuralgia and ocular symptoms were associated with the corneal injury ( P<0.05 ). Multivariate logistic regression analysis showed the location ( trigeminal nerve , OR=0.166 ), long-term use of immunosuppressive agents ( OR=2.773 ), distribution of skin lesions ( trigeminal nerve , OR=0.771 ) and complicated with ocular symptoms ( OR=3.313 ) were correlated with the corneal injury ( P<0.05 ). Conclusion It is necessary for the clinicians to pay high attention to the risk factors for corneal injury in patients with facial herpes zoster and to conduct positive treatment in early stage.

关 键 词：带状疱疹 角膜损伤 危险因素 病例对照研究 

分 类 号：R772.21[医药卫生—眼科]