多发肺结节的基础研究和临床治疗进展  

Progress in Basic Research and Clinical Treatment of Multiple Pulmonary Nodules

作　　者：吴雪杰 陈东来[2] 朱蓉英[1] 王一飞 陈昶[2] 陈勇兵[1] 杨文涛[1] Xuejie WU;Donglai CHEN;Rongying ZHU;Yifei WANG;Chang CHEN;Yongbing CHEN;Wentao YANG(Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China;Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China)

机构地区：[1]苏州大学附属第二医院胸心外科,苏州215000 [2]同济大学附属上海市肺科医院胸外科,上海200433

出　　处：《中国肺癌杂志》2019年第3期173-177,共5页Chinese Journal of Lung Cancer

摘　　要：肺癌是世界上发病率和死亡率最高的肿瘤。随着多层螺旋计算机断层扫描(computed tomography,CT)技术的发展和肺癌筛查的广泛开展,越来越多的肺结节被发现,其中不少是多发肺结节,这些结节在病理学上常被诊断为多原发肺腺癌。对于具有不同影像学特征的多发结节,首选处理方法不尽相同,且每个肺结节的处理方法仍存在很大争议。近年来多发肺结节各病灶的演进及病灶间的相互影响机制,病灶内和病灶间肿瘤细胞在基因组学方面的同质性和异质性也备受关注。本文从组织病理学、基因组学、外科处理等多方面综合论述多发肺结节的研究进展。Lung cancer leads to the highest cancer-related morbidity and mortality worldwide. With the development of multi-slice spiral computed tomography technology and the implement of lung cancer screening, more and more lung nodules have been discovered, many of which are multiple pulmonary nodules. These pulmonary nodules are usually diagnosed as multiple primary lung adenocarcinomas from a pathological perspective. For multiple nodules with different imaging features, the preferred treatment methods are different, and the treatment of each lung nodule is still controversial. In recent years, the interactions between multiple lesions and the evolution of the lesions as well as the inter-tumoral and intratumoral homogeneity and heterogeneity of the genomics also arouse attention. Our review gathered the research progress in multiple pulmonary nodules from the points of histopathology, genomics and surgical management.

关 键 词：肺肿瘤 多发肺结节 基因组学 外科治疗 

分 类 号：R734.2[医药卫生—肿瘤]