血小板计数和D-二聚体水平联合检测在肺癌中的临床意义  

Clinical Significance of Combined Detection of Platelet Count and D-dimer Level in Lung Cancer

作　　者：程清 陈国荣[2] 李君艳[2] 王珍珍 马晓 黄盼盼 Cheng Qing;Chen Guorong;Li Junyan;Wang Zhenzhen;Ma Xiao;Huang Panpan(Third Medical College, Xinxiang Medical University, Xinxiang 453000, Henan, China;Second Department of Medical Oncology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, Henan, China ( Chen Guorong, Li Junyan, Wang Zhenzhen, Ma Xiao)

机构地区：[1]新乡医学院第三临床学院,河南新乡453000 [2]新乡医学院第三附属医院肿瘤内二科,河南新乡453000

出　　处：《肿瘤预防与治疗》2019年第3期228-232,共5页Journal of Cancer Control And Treatment

基　　金：河南省医学科技攻关计划项目(编号:201503138);河南省高等学校重点科研项目计划(编号:16A320041);新乡市第一批科技创新发展专项项目(编号:CXGG16016)~~

摘　　要：目的:探讨外周血中血小板(platelet, PLT)计数和D-二聚体(D-dimer, D-D)水平单项或联合检测在肺癌中的临床意义。方法:收集107例初治肺癌患者和94例健康体检者的临床资料,对两组研究对象的临床资料及PLT计数、D-D水平进行比较,通过计算PLT计数、D-D水平单项或联合检测的灵敏度、特异度、约登指数、曲线下面积(AUC),发现PLT计数及D-D水平在肺癌中的临床意义。结果:PLT计数、D-D水平在观察组明显高于对照组,差异有统计学意义(P<0.05)。在观察组中,Ⅲ～Ⅳ期肺癌患者的PLT计数、D-D水平明显高于I～Ⅱ期患者,差异有统计学意义(P<0.05)。PLT计数、D-D联合检测的灵敏度、曲线下面积高于单项检测。结论:PLT计数、D-D水平单项或联合检测在肺癌中均有一定的临床价值,联合检测的临床价值相对较高。Objective: To study the clinical significance of separate or combined detection of platelet count and D-dimer level in peripheral blood in lung cancer. Methods: Clinical data of 107 previously untreated lung cancer patients and 94 healthy people were collected. The two groups were compared in clinical data, platelet count and D-dimer level. And we calculated sensitivity, specificity, Youden index and area under curve(AUC) of separate or combined detection of platelet count and D-dimer level to determine the clinical significance of platelet count and D-dimer level in lung cancer. Results: Platelet count and D-dimer level were significantly higher in the observation group than those in the control group(P<0.05). In the observation group, platelet count and D-dimer level of patients with Ⅲ-Ⅳ stage tumors were significantly higher than those of patients with I-Ⅱ stage tumors(P<0.05). Sensitivity and AUC of combined detection of platelet count and D-dimer level were higher than those of separate detection of platelet count and D-dimer level. Conclusion: Separate or combined detection of platelet count and D-dimer level in lung cancer has certain clinical significance in the diagnosis of lung cancer, and the clinical significance of combined detection is higher.

关 键 词：肺癌 PLT计数 D-D水平 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]