乳腺癌患者血清CYFRA21-1 TK1及CA15-3表达与预后相关性分析  

Expression and the Correlation with Prognosis of Levels of Serum CYFRA21-1 TK1 and CA15-3 in Patients with Breast Cancer

作　　者：吴彬[1] 聂琛[1] 佟萌 WU Bin;NIE Chen;TONG Meng(Zhongshan Hospital Affiliated to Dalian University, Liaoning Dalian 116001, China)

机构地区：[1]大连大学附属中山医院乳腺甲状腺外科,辽宁大连116001

出　　处：《河北医学》2019年第4期529-532,共4页Hebei Medicine

基　　金：辽宁省科技攻关计划项目;(编号:20152710642)

摘　　要：目的:探讨血清C角蛋白19片段抗原21-1(CYFRA21-1)、血清胸苷激酶1(TK1)、及糖链抗原15-3(CA15-3)在乳腺癌患者中表达及其与预后相关性分析。方法:回顾性分析2013年1月至2015年1月间收治的90例乳腺癌患者(乳腺癌组)临床资料,并选取同期良性乳腺肿瘤患者50例作为对照组。比较两组血清CYFRA21-1、TK1及CA15-3指标水平及阳性率,分析乳腺癌组3年复发转移情况,应用logistics回归分析CYFRA21-1、TK1及CA15-3指标水平与乳腺癌预后的相关性。结果:①乳腺癌组血清CYFRA21-1、TK1及CA15-3指标水平和指标阳性率均高于对照组(P<0.05);②复发组CYFRA21-1、TK1及CA15-3指标水平高于未复发组(P <0.05),转移组CYFRA21-1、TK1及CA15-3指标水平高于未转移组(P<0.05);③Spearman相关性分析显示:CYFRA21-1、TK1及CA15-3指标水平均与乳腺癌复发、转移存在正相关关系(P<0.05)。结论:血清CYFRA21-1、TK1及CA15-3指标水平高表达与乳腺癌发生、术后复发转移相关,可有效预测术后复发转移。Objective: To explore the expression levels of serum C cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), serum thymidine kinase 1 (TK1) and carbohydrate antigen 15-3 (CA15-3) in patients with breast cancer and their correlation analysis with prognosis. Methods: The clinical data of 90 patients with breast cancer (breast cancer group) admitted from January 2013 to January 2015 were retrospectively analyzed. Another 50 patients with benign breast tumors at the same time period were selected as control group. The levels and positive rates of serum CYFRA21-1, TK1 and CA15-3 were compared between the two groups. The recurrence and metastasis at 3 years were recorded in breast cancer group. The correlation between levels of CYFRA21-1, TK1 and CA15-3 and prognosis of breast cancer was analyzed by logistic regression analysis. Results: The levels and positive rates of serum CYFRA21-1, TK1 and CA15-3 in breast cancer group were higher than those in control group (P<0.05). The levels of CYFRA21-1, TK1 and CA15-3 in recurrence group were higher than those in non-recurrence group (P<0.05), and the levels of CYFRA21-1, TK1 and CA15-3 in metastasis group were higher than those in non-metastasis group (P<0.05). Spearman analysis showed that the levels of CYFRA21-1, TK1 and CA15-3 were positively correlated with recurrence and metastasis of breast cancer (P<0.05). Conclusions: The high expression levels of serum CYFRA21-1, TK1 and CA15-3 are associated with occurrence, postoperative recurrence and metastasis of breast cancer, and can effectively predict the postoperative recurrence and metastasis.

关 键 词：乳腺癌 C角蛋白19片段抗原21-1 胸苷激酶1 糖链抗原15-3 

分 类 号：R737.9[医药卫生—肿瘤]