Hormones induce the formation of luminal-derived basal cells in the mammary gland  

作　　者：Wenqian Song Ran Wang Weimin Jiang Qi Yin Guangdun Peng Ruikai Yang Qing Cissy Yu Jianfeng Chen Jingsong Li Tom H. Cheung Naihe Jing Yi Arial Zeng 

机构地区：[1]State Key Laboratory of Cell Biology, CAS Center for Excellenee in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China [2]CAS Key Laboratory of Regenerative Biology and South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China [3]Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou 510005, China [4]Division of Life Science, Center for Stem Cell Research, Center for Systems Biology and Human Health, the State Key Laboratory in Neuroscience, Hong Kong University of Science & Technology, Kowloon, Hong Kong, China

出　　处：《Cell Research》2019年第3期206-220,共15页细胞研究（英文版）

基　　金：grants fromNational Natural Science Foundation of China (31830056, 31861163006, 31625020,31530045, 31661143043 to Y.A.Z.;31871456, 31661143042, 91519314, 31630043,31571513, 31430058 to NJ.);Chinese Academy of Sciences (XDB19000000 andXDA12020349 to Y.A.Z.;XDA16020501 to NJ.Z XDA16020404 to G.P.);Ministry ofScience and Technology of China (2018YFA0108000, 2017YFA0102700,2015CB964500 to NJ., 2018YFA0107201 to G.P.);Research Grants Council(N_HKUST628/18 to T.H.C);Shanghai Municipal Science and Technology Commission(17XD1404000 to YAZ).

摘　　要：In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexpected potential of luminal cells that can give rise to basal cells during pregnancy. These luminal-derived basal cells (LdBCs) persisted through mammary regression and gen erated more proge ny in successive rounds of preg nan cies. LdBCs express basal markers as well as estroge n receptor a (ERa). I n ovariectomized (OVX) mice, stimulation with estrogen and progesterone promoted the formation of LdBCs. In serial transplantation assays, LdBCs were able to rec on stitute new mammary glands in a hormone-depende nt manner. Tran scriptome an alysis and genetic experiments suggest that Wnt/p-catenin signaling is essential for the formation and maintenance of LdBCs. Our data uncover an unexpected bi-potency of luminal cells in a physiological context. The discovery of ERa+ basal cells, which can respond to hormones and are endowed with stem cell-like regenerative capacity in parous mammary gland, provides new insights into the association of hormones and breast cancer.

关 键 词：HORMONES INDUCE luminal-derived basal cells MAMMARY GLAND 

分 类 号：Q[生物学]