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作品数：325被引量：1019H指数：15
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Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
《World Journal of Diabetes》2025年第4期19-24,共6页Meng Gao Meng-Ting Dai Guo-Hua Gong 
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...
关键词：Glucose metabolism Sodium-D-glucose cotransporter 1 Glucose reabsorption Mitochondrial dysfunction Reactive oxygen species Inflammation 
Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1
《Bio-Design and Manufacturing》2025年第2期288-309,I0005-I0011,共29页Qing Zhang Chengxun He Juan Guo Dandan Tang Die Qian Chuan Zheng Chunjie Wu Wei Peng 
supported by the Natural Science Foundation of Sichuan Province(No.2022NSFSC0720);Research Center for the Development of the Comprehensive Health Industry and Rural Revitalization of Sichuan TCM(No.DJKYB202306);State Administration of Traditional Chinese Medicine of Sichuan Province of China(No.2020HJZX001).
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy...
关键词：Hydroxy-α-sanshool Adipocyte targetability Mesoporous silica nanoparticles White adipose tissue browning OBESITY 
Single-atomic iron synergistic atom-cluster induce remote enhancement toward oxygen reduction reaction
《Journal of Energy Chemistry》2025年第3期413-420,共8页Yayin Li Haomin Jiang Liu Lin Zemin Sun Genban Sun 
supported by the National Natural Science Foundations of China(Nos:22271018,22309012 and 22302013);the NSF of Guangdong Province(Nos:2023A1515010554 and 2024A1515010307)。
The oxygen reduction reaction(ORR)could be effectively regulated by adjusting electron configurations and optimizing chemical bonds.Herein,we have achieved the modulation of electron distribution in Fe single atomic(F...
关键词：Single atomic catalysts Atom-cluster induce effect Oxygen reduction reaction Fe-N4 sites 
Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice
《Science China(Life Sciences)》2025年第3期777-792,共16页Yiling Zhou Chaofeng Tu Charles Coutton Jianan Tang Shixiong Tian Shuyan Tang Guillaume Martinez Dapeng Zhou Célia Tebbakh Jiaxiong Wang Raoudha Zouari Xuehai Zhou Selima Fourati Ben Mustapha Xuemei Wang Bangguo Wu Xinyan Geng Shuang Liu Li Jin Huijuan Shi Yue-Qiu Tan Pierre FRay Lingbo Wang Xiaoyu Yang Feng Zhang Chunyu Liu 
supported by the National Natural Science Foundation of China(32288101,32100480,32370654,82271638,32322017);the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);Shanghai Hospital Development Center Foundation(SHDC12023121);the outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China(2023JJ20080).
Asthenoteratozoospermia is a common cause of male infertility.To further define the genetic causes underlying asthenoteratozoospermia,we performed whole-exome sequencing in a cohort of Han Chinese men with asthenotera...
关键词：male infertility asthenoteratozoospermia MYCBPAP acrosome biogenesis MANCHETTE AXONEME 
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis
《Research》2025年第1期497-516,共20页Nuo Chen Xinyi Xu Yaxin Guo Ming Zhao Yubin Li Tian Zhou Xinyue Zhang Jie Gao Faliang Zhu Chun Guo Yongyu Shi Qun Wang Wenxian Wu Lining Zhang Yan Li 
supported by the National Natural Science Foundation of China(82101606,82173105,81771775,81971471,and 32270800);Shandong Excellent Young Scientists Fund Program(Overseas)(2022HWYQ-028);Shandong Provincial Natural Science Foundation(ZR2022MC012).
Short-chain fatty acids(SCFAs)have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiot...
关键词：microbiota gut brain axis gut microbiota depressive behavior brain short chain fatty acids bioactive metabolites 
Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression
《World Journal of Gastroenterology》2025年第1期126-145,共20页Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang 
Supported by the Haihe Laboratory of Cell Ecosystem Innovation Fund,No.22HHXBJC00001;the Key Discipline Special Project of Tianjin Municipal Health Commission,No.TJWJ2022XK016.
BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated mortality.Efficient therapeutic targets are beneficial to treat and predict the disease.Currently,the exact mo...
关键词：Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis 
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy
《Acta Pharmaceutica Sinica B》2025年第1期526-541,共16页Danni Liu Yaoqi Wang Qi Sun Dong Mei Xiaoling Wang Yan Su Jie Zhang Ran Huo Yang Tian Siyu Liu Shuang Zhang Chunying Cui 
supported by the National Natural Science Foundation of China(81502688);Cooperation Research Funding of Capital Medical University(2020KJ000514,China);Cooperation Research Funding of Capital Medical University(2023KJ000814,China);R&D Program of Beijing Municipal Education Commission(KM202210025024,China).
Ferroptosis has received great attention as an iron-dependent programmed cell death for efficient cancer therapy.However,with the accumulation of iron in tumor cells,the antioxidant system is activated by reducing glu...
关键词：Ferroptosis FERRITIN Iron homeostasis SIRNA Gene silencing Glutathione peroxidase 4 ANTITUMOR Lipid peroxidation 
Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response
《Science China Chemistry》2025年第1期273-287,共15页Shuguang Yang Lijun Hu Hong Xiao Zecong Xiao Xintao Shuai 
supported by the Key Areas Research and Development Program of Guangzhou(202007020006);the National Natural Science Foundation of China(51933011,31971296,82102194,82302360);the Science and Technology Projects of Guangzhou(2023A03J0215);the Guangdong Basic Research Center of Excellence for Functional Molecular Engineering。
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy.Nonetheless,the optimization of the catal...
关键词：fluorescent molecular probes self-amplifying MYELOPEROXIDASE photodynamic therapy 
The diterpenoid esters from Euphorbia lathyris L. induce intestinal inflammation via LXRα/ABCA1-regulated lipid rafts and TLR4-mediated pathway
《Natural Therapy Advances》2024年第4期30-37,共8页Hui-Nan Wang Xiao-Yu Wang Pei-Hua Wang Ming-Rui Jiang Si-Yuan Ma Hai-Ting Zhu Jun-Li Zhang Xin-Ning Zhang Wen-Jing Chen Yi-Fan Mao Hua Xu Ying-Zi Wang 
supported by the National Natural Science Foundation of China(Grant no.82074021,82374040);the Beijing Nova Program(Grant no.20240484548).
Background:Diterpenoid esters are considered to be the main toxic components and bioactive constituents of Euphorbia lathyris L.(EL).Euphorbia factors L1(EF1),L2(EF2),and L3(EF3),the main diterpenoid esters of EL,have...
关键词：diterpenoid esters Euphorbia lathyris L. LXRα/ABCA1 lipid rafts TLR4 
IEC Materials as Tools to Induce Climate Action as Perceived by Coastal Communities in Zambales, Philippines
《American Journal of Climate Change》2024年第4期697-719,共23页Roann P. Alberto Anastacia S. Mendoza Annie Melinda Paz-Alberto 
IEC materials promote climate action and affect community behavior. The purpose of the study was to find out how local communities perceived about IEC materials on community-based adaptation techniques and ecosystem-b...
关键词：Perception Coastal Communities IEC Materials IEC Materials Attributes Climate Change Adaptation Strategies Climate Action Coastal Municipalities 
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