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作品数：319被引量：1007H指数：15
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Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
《World Journal of Diabetes》2025年第4期19-24,共6页Meng Gao Meng-Ting Dai Guo-Hua Gong 
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...
关键词：Glucose metabolism Sodium-D-glucose cotransporter 1 Glucose reabsorption Mitochondrial dysfunction Reactive oxygen species Inflammation 
Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1
《Bio-Design and Manufacturing》2025年第2期288-309,I0005-I0011,共29页Qing Zhang Chengxun He Juan Guo Dandan Tang Die Qian Chuan Zheng Chunjie Wu Wei Peng 
supported by the Natural Science Foundation of Sichuan Province(No.2022NSFSC0720);Research Center for the Development of the Comprehensive Health Industry and Rural Revitalization of Sichuan TCM(No.DJKYB202306);State Administration of Traditional Chinese Medicine of Sichuan Province of China(No.2020HJZX001).
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy...
关键词：Hydroxy-α-sanshool Adipocyte targetability Mesoporous silica nanoparticles White adipose tissue browning OBESITY 
Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice
《Science China(Life Sciences)》2025年第3期777-792,共16页Yiling Zhou Chaofeng Tu Charles Coutton Jianan Tang Shixiong Tian Shuyan Tang Guillaume Martinez Dapeng Zhou Célia Tebbakh Jiaxiong Wang Raoudha Zouari Xuehai Zhou Selima Fourati Ben Mustapha Xuemei Wang Bangguo Wu Xinyan Geng Shuang Liu Li Jin Huijuan Shi Yue-Qiu Tan Pierre FRay Lingbo Wang Xiaoyu Yang Feng Zhang Chunyu Liu 
supported by the National Natural Science Foundation of China(32288101,32100480,32370654,82271638,32322017);the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);Shanghai Hospital Development Center Foundation(SHDC12023121);the outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China(2023JJ20080).
Asthenoteratozoospermia is a common cause of male infertility.To further define the genetic causes underlying asthenoteratozoospermia,we performed whole-exome sequencing in a cohort of Han Chinese men with asthenotera...
关键词：male infertility asthenoteratozoospermia MYCBPAP acrosome biogenesis MANCHETTE AXONEME 
Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression
《World Journal of Gastroenterology》2025年第1期126-145,共20页Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang 
Supported by the Haihe Laboratory of Cell Ecosystem Innovation Fund,No.22HHXBJC00001;the Key Discipline Special Project of Tianjin Municipal Health Commission,No.TJWJ2022XK016.
BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated mortality.Efficient therapeutic targets are beneficial to treat and predict the disease.Currently,the exact mo...
关键词：Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis 
Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response
《Science China Chemistry》2025年第1期273-287,共15页Shuguang Yang Lijun Hu Hong Xiao Zecong Xiao Xintao Shuai 
supported by the Key Areas Research and Development Program of Guangzhou(202007020006);the National Natural Science Foundation of China(51933011,31971296,82102194,82302360);the Science and Technology Projects of Guangzhou(2023A03J0215);the Guangdong Basic Research Center of Excellence for Functional Molecular Engineering。
Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy.Nonetheless,the optimization of the catal...
关键词：fluorescent molecular probes self-amplifying MYELOPEROXIDASE photodynamic therapy 
The diterpenoid esters from Euphorbia lathyris L. induce intestinal inflammation via LXRα/ABCA1-regulated lipid rafts and TLR4-mediated pathway
《Natural Therapy Advances》2024年第4期30-37,共8页Hui-Nan Wang Xiao-Yu Wang Pei-Hua Wang Ming-Rui Jiang Si-Yuan Ma Hai-Ting Zhu Jun-Li Zhang Xin-Ning Zhang Wen-Jing Chen Yi-Fan Mao Hua Xu Ying-Zi Wang 
supported by the National Natural Science Foundation of China(Grant no.82074021,82374040);the Beijing Nova Program(Grant no.20240484548).
Background:Diterpenoid esters are considered to be the main toxic components and bioactive constituents of Euphorbia lathyris L.(EL).Euphorbia factors L1(EF1),L2(EF2),and L3(EF3),the main diterpenoid esters of EL,have...
关键词：diterpenoid esters Euphorbia lathyris L. LXRα/ABCA1 lipid rafts TLR4 
IEC Materials as Tools to Induce Climate Action as Perceived by Coastal Communities in Zambales, Philippines
《American Journal of Climate Change》2024年第4期697-719,共23页Roann P. Alberto Anastacia S. Mendoza Annie Melinda Paz-Alberto 
IEC materials promote climate action and affect community behavior. The purpose of the study was to find out how local communities perceived about IEC materials on community-based adaptation techniques and ecosystem-b...
关键词：Perception Coastal Communities IEC Materials IEC Materials Attributes Climate Change Adaptation Strategies Climate Action Coastal Municipalities 
On how water injection may induce fault reactivation and slippage:A numerical method
《Petroleum》2024年第4期646-659,共14页Hao Yu Yuheng Tuo Tiejun Lin Min Li Zhanghua Lian 
support from the National Natural Science Foundation of China(No.52104008&No.52204012);Key Project of Natural Science of Sichuan Education Department(No.14ZA0037).
During the water injection process in oil fields,the original stress equilibrium of faults might be disrupted by the large influx of fluids into the reservoir,resulting in movements.Fault slip may lead to the leakage ...
关键词：Reservoir-scale Fault slip Geomechanics model Fault gouge Friction coefficient 
Does HSP27 injection induce glaucoma damage in mice?
《Neural Regeneration Research》2024年第11期2347-2348,共2页Stephanie C.Joachim Sabrina Reinehr 
supported by FoRUM(Ruhr-University Bochum,Germany,to SCJ);the Deutsche Forschungsgemeinschaft(DFG,Germany,RE-4543/1-1,to SR).
In a further aging society,excellent eyesight is an integral part of overall well-being and quality of life.Preserving good vision is crucial to maintaining mobility,independence,and mental health.There can be several...
关键词：HSP27 INJECTION DAMAGE 
DNAJA4, DNAJB11 and DNAJC10 induce cell transformation by inhibiting p53 and oncogene-induced senescence
《BIOCELL》2024年第10期1455-1464,共10页HYEON JU LEE CHANG SEOP LEE SI HOON KIM SOOKYUNG KIM JEONG MI KIM SUN-WHA IM YU-JIN JUNG SEUNG-PYO HONG HYUNJUNG LEE JONG-IL KIM JEONG A.HAN 
National Research Foundation of Korca(NRF)grant funded by the Korea goverment(MSIT)(No.2016R1 A2B4012817);research grant of Kangwon National University in 2022.
Objective:Transformation from normal cells to malignant cells is the basis for tumorigenesis.While this cell transformation is known to result from aberrant activation or inactivation of associated genes,these genes h...
关键词：DNAJA4 DNAJB11 DNAJC10 P53 SENESCENCE TRANSFORMATION 
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