Approach to 2′-(Dialkylamino)-1-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts withα-Hydroxy andβ-Carbonyl Amides  

作　　者：DAI Jianan LIU Bengen WEI Zhonglin CAO Jungang LIANG Dapeng DUAN Haifeng LIN Yingjie 

机构地区：[1]Department of Organic Chemistry,College of Chemistry,Jilin University,Changchun 130012,R R. China

出　　处：《Chemical Research in Chinese Universities》2019年第2期216-220,共5页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China(No.51373067).

摘　　要：A straiglitforward and efficient synthetic method of 2′-(dialkylammo)-l-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 2-(dialkylamino)-5,6-dihydro-4H-naphtho[2,1-e][1,3]oxazin-4-one-derivatives have been developed from a-hydroxy andβ-carbonyl amides and various Vilsmeier salts.A wide range of heterocyclic compounds were obtained in excellent yields(up to 97%),which will provide promising candidates lor chemical biology and drug discovery.

关 键 词：SPIROOXINDOLE unit 2-Oxazolin-4-ones CORE STRUCTURE 3-Oxazin-4-ones CORE STRUCTURE 

分 类 号：TP303[自动化与计算机技术—计算机系统结构]