SPIROOXINDOLE

作品数：21被引量：16H指数：3
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相关领域：理学更多>>
相关作者：颜朝国李健更多>>
相关机构：扬州大学广西师范学院上海大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Chinese Journal of Structural Chemistry》《Green Synthesis and Catalysis》《Chinese Journal of Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划江苏省杰出青年基金更多>>
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Catalytic Asymmetric[4+2]Cyclization of Hydroxyphenyl Indolinone with Azlactone to Construct Spirooxindoleδ-Lactone
《Chinese Journal of Chemistry》2024年第24期3362-3366,共5页Xuerui Wang Weiwu Ren 
We thank the Qingdao Marine Science and Technology Center(No.2022QNLM030003-2);the Fundamental Research Funds for the Central Universities,Taishan Scholar Program of Shandong Province(No.tsqn201909056);National Natural Science Foundation of China(No.22171251)for financial support.
An efficient asymmetric[4+2]cyclization of hydroxyphenyl indolinone with azlactone for the synthesis of spirooxindoleδ-lactone has been developed,which realized the first asymmetric reaction of hydroxyphenyl indolino...
关键词：Asymmetric synthesis Hydroxyphenyl indolinone AZLACTONE Spirooxindoleδ-lactone Quaternary stereocenter 
Modular Assembly of Six-Membered Carbocyclic Spirooxindoles via Peterson Olefination/Michael Addition/C(sp^(3))Arylation Cascade
《Chinese Journal of Chemistry》2024年第21期2614-2620,共7页Feng-Cheng Jia Zi-Yi Yuan Na Luo Shuang-Xi Gu Xiao-Qiang Hu 
financial support of National Natural Science Foundation of China(21901193,22271314 and 22377097);the innovation foundation of Key Laboratory of Green Chemical Engineering Process of Ministry of Education(GCX2023002).
Concise assembly of spirooxindoles is of great significance but a challenging task in modern organic synthesis.Described herein is an unusual base-promoted[4+2]spiroannulation of rarely used isatin-derivedβ-silylcarb...
关键词：Cascade reaction SPIROOXINDOLE Peterson olefination C(sp^(3))arylation of oxindole Transition-metal-free 
Diastereoselective synthesis of spiro[chromane-3,30-indolines]and spiro[chromane-3,20-indenes]via DBU promoted formal[4+2]cycloaddition reaction
《Green Synthesis and Catalysis》2022年第1期53-58,共6页Daqian Wang Jing Sun Chao-Guo Yan 
We are grateful to the National Natural Science Foundation of China(Nos.21572196,21871227);the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.BK2013016)for financial support.
A new DBU-catalyzed formal[4+2]cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was establis...
关键词：ortho-Quinone methide para-Quinone methide Indene-1 3-dione SPIROOXINDOLE [4+2]cycloaddition 
Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells被引量：1
《Organic Chemistry Frontiers》2022年第4期1048-1055,共8页Xiang-Hong He Xue-Ju Fu Gu Zhan Nan Zhang Xiang Li Hong-Ping Zhu Cheng Peng Gu He Bo Han 
We are grateful for the financial support from the National Natural Science Foundation of China(81773889,22001024,82073998);the Sichuan Science and Technology Program(22CXRC0077,2021YFS0044);the Xinglin Scholar Research Premotion Project of Chengdu University of TCM.
Organocatalytic asymmetric[3+3]annulations of isatin-derived MBH carbonates and indolin-2-imines were efficiently achieved.This appears to be the first enantioselective approach for using isatin-derived MBH carbonates...
关键词：ASYMMETRIC INDOLE CATALYTIC 
Stereoselective 1,2-Dicarbofunctionalization of Trisubstituted Alkenes by Palladium-Catalyzed Heck/Suzuki or Heck/Sonogashira Domino Sequence
《CCS Chemistry》2021年第9期2340-2349,共10页Jia-Wen Zhu Bo Zhou Zhong-Yan Cao Ren-Xiao Liang Yi-Xia Jia 
support from the National Natural Science Foundation of China(nos.21702184,21772175,and 91956117).
Highly enantioselective and diastereoselective 1,2-diarylation and 1,2-arylalkynylation of trisubstituted alkenes are reported via the palladium-catalyzed Heck/Suzuki or Heck/Sonogashira domino sequence.These alkenes ...
关键词：asymmetric catalysis palladium SPIROOXINDOLE dicarbofunctionalization trisubstituted alkene 
NHC-catalysed retro-aldol/aldol cascade reaction enabling solvent-controlled stereodivergent synthesis of spirooxindoles被引量：1
《Chinese Chemical Letters》2021年第8期2567-2571,共5页Haijun Leng Qian Zhao Qing Mao Shuaijiang Liu Menglan Luo Rui Qin Wei Huang Gu Zhan 
financial support from Ministry of Science and Technology of China (No.2019ZX09721001-008);National Natural Science Foundation of China (Nos.81773890,22001024,82073997);the “Thousand Talents Program” of Sichuan Province and Xinglin Scholar Research Premotion Project of CDUTCM。
An N-heterocyclic carbene(NHC)-catalysed retro-aldol/aldol cascade reaction of spirooxindole-basedβ-hydroxyaldehyde has been developed.The ring opening-closure process enables the diastereodivergent synthesis of spir...
关键词：Asymmetric synthesis Solvent-controlled diastereodivergence Retro-aldol/aldol Cascade reaction SPIROOXINDOLE N-Heterocyclic carbene catalysis 
Discovery of spirooxindole-ferrocene hybrids as novel MDM2 inhibitors被引量：1
《Chinese Chemical Letters》2021年第6期1897-1901,共5页Jun Mu Xin Xie Shanshan Xiong Yuehua Zhang Yuting Wang Qian Zhao Hongping Zhu Wei Huang Gu He 
supported by grants from the National Natural Science Foundation(Nos.21772131,81672552,81773890,82073997);the Fundamental Research Funds of Science&Technology Department of Sichuan Province(Nos.2019YFSY0004,2017JY0226,2019YFS0298);Project First-Class Disciplines Development supported by CDUTCM。
A series of spirooxindole-ferrocene hybrids bearing five or four contiguous chiral centers were designed and synthesized via organocatalysis.In vitro protein binding and cellular proliferation assays suggested that co...
关键词：SPIROOXINDOLE FERROCENE MDM2 Apoptosis Breast cancer 
Protecting-Group-Free Total Synthesis and Biological Investigation of Cabucine Oxindole A被引量：2
《Chinese Journal of Chemistry》2021年第1期137-142,共6页Shengling Xie Chengqing Ning Qingzhen Yu Jieping Hou Jing Xu 
Financial support from SZSTI(Nos.JCY120170817110515599,KQTD20150717103157174);the National Natural Science Founda tion of China(Nos.21772082 and 21971104);the Guangdong Innovative Program(No.2019BT02Y335);the Guangdong Provin cial Key Laboratory of Catalysis(No.2020B121201002);the Shen zhen Key Laboratory of Small Molecule Drug Discovery and Syn thesis(No.ZDSY520190902093215877);the Shenzhen Nobel Prize Scientists Laboratory Project(C17783101)is greatly appreci-ated.The authors are grateful to Prof.Qing Ye(SUSTech)for assis-tance with XRD analysis.
Owing to their challenging structures and promising biological profiles,spirooxindole alkaloids have long attracted much attention from the synthetic community.Herein,we wish to describe a concise,protecting-group-fre...
关键词：Protecting-group-free Total synthesis SPIROOXINDOLE ALKALOID Asymmetric synthesis 
Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma被引量：2
《Acta Pharmaceutica Sinica B》2020年第8期1492-1510,共19页Biao Wang Fu Peng Wei Huang Jin Zhou Nan Zhang Jia Sheng Phensinee Haruehanroengra Gu He Bo Han 
financial support from the National Natural Science Foundation of China(81573588,81630101,81773889 and 21772131);the Science&Technology Department of Sichuan Province(2017JZYD0001,2017JQ0002,2017JY0323 and 2019YFSY0004,China)
Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene(THN)-oxindole hybrids for this purpose have been developed. Appropr...
关键词：MDM2 GLIOBLASTOMA CDK4 
Approach to 2′-(Dialkylamino)-1-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts withα-Hydroxy andβ-Carbonyl Amides
《Chemical Research in Chinese Universities》2019年第2期216-220,共5页DAI Jianan LIU Bengen WEI Zhonglin CAO Jungang LIANG Dapeng DUAN Haifeng LIN Yingjie 
the National Natural Science Foundation of China(No.51373067).
A straiglitforward and efficient synthetic method of 2′-(dialkylammo)-l-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 2-(dialkylamino)-5,6-dihydro-4H-naphtho[2,1-e][1,3]oxazin-4-one-derivatives have been ...
关键词：SPIROOXINDOLE unit 2-Oxazolin-4-ones CORE STRUCTURE 3-Oxazin-4-ones CORE STRUCTURE 
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