Stereoselective 1,2-Dicarbofunctionalization of Trisubstituted Alkenes by Palladium-Catalyzed Heck/Suzuki or Heck/Sonogashira Domino Sequence  

作　　者：Jia-Wen Zhu Bo Zhou Zhong-Yan Cao Ren-Xiao Liang Yi-Xia Jia 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014 [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032

出　　处：《CCS Chemistry》2021年第9期2340-2349,共10页中国化学会会刊（英文）

基　　金：support from the National Natural Science Foundation of China(nos.21702184,21772175,and 91956117).

摘　　要：Highly enantioselective and diastereoselective 1,2-diarylation and 1,2-arylalkynylation of trisubstituted alkenes are reported via the palladium-catalyzed Heck/Suzuki or Heck/Sonogashira domino sequence.These alkenes represent an extension of enantioselective dicarbofunctionalization from terminal alkenes to trisubstituted ones based on anionic capture of the secondary alkyl-Pd intermediate.

关 键 词：asymmetric catalysis palladium SPIROOXINDOLE dicarbofunctionalization trisubstituted alkene 

分 类 号：O62[理学—有机化学]