Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells  

作　　者：Xiang-Hong He Xue-Ju Fu Gu Zhan Nan Zhang Xiang Li Hong-Ping Zhu Cheng Peng Gu He Bo Han 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,Hospital of Chengdu University of Traditional Chinese Medicine,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [2]State Key Laboratory of Biotherapy and Department of Pharmacy,West China Hospital,Sichuan University,Chengdu,610041,China [3]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,Chengdu University,Chengdu 610052,China

出　　处：《Organic Chemistry Frontiers》2022年第4期1048-1055,共8页有机化学前沿（英文）

基　　金：We are grateful for the financial support from the National Natural Science Foundation of China(81773889,22001024,82073998);the Sichuan Science and Technology Program(22CXRC0077,2021YFS0044);the Xinglin Scholar Research Premotion Project of Chengdu University of TCM.

摘　　要：Organocatalytic asymmetric[3+3]annulations of isatin-derived MBH carbonates and indolin-2-imines were efficiently achieved.This appears to be the first enantioselective approach for using isatin-derived MBH carbonates as 3C synthons to react with indole-derived C,N-dinucleophiles,yielding a series of multifunctionalized α-carboline-spirooxindole hybrids in good to high yields with high stereoselectivities.

关 键 词：ASYMMETRIC INDOLE CATALYTIC 

分 类 号：O62[理学—有机化学]