Diastereoselective synthesis of spiro[chromane-3,30-indolines]and spiro[chromane-3,20-indenes]via DBU promoted formal[4+2]cycloaddition reaction  

作　　者：Daqian Wang Jing Sun Chao-Guo Yan 

机构地区：[1]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Green Synthesis and Catalysis》2022年第1期53-58,共6页绿色合成与催化（英文）

基　　金：We are grateful to the National Natural Science Foundation of China(Nos.21572196,21871227);the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.BK2013016)for financial support.

摘　　要：A new DBU-catalyzed formal[4+2]cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was established.A wide range of functionalized spiro[chromane-3,30-indolines]and spiro[chromane-3,20-indenes]were successfully synthesized in good yields and with high diastereoselectivity.The features of the reaction included readily available substrates,mild reaction conditions,convenient methodology and good functional group tolerance.

关 键 词：ortho-Quinone methide para-Quinone methide Indene-1 3-dione SPIROOXINDOLE [4+2]cycloaddition 

分 类 号：O62[理学—有机化学]