Mondo蛋白在肿瘤相关代谢中的研究进展  

Progress on roles of transcription factor Mondo proteins in tumor metabolism

作　　者：张俊华 薛敏[1] 肖松舒[1] 易水晶[1] 曾飞[1] ZHANG Junhua;XUE Min;XIAO Songshu;YI Shuijing;ZENG Fei(Department of Gynecology,The Third Xiangya Hospital,Central South University,Changsha 410000,China)

机构地区：[1]中南大学湘雅三医院妇科,长沙410000

出　　处：《生命的化学》2019年第1期88-95,共8页Chemistry of Life

摘　　要：转录因子Mondo蛋白家族包括MondoA和ChREBP(MondoB)两个家族成员,是葡萄糖介导的基因转录调控的关键调控因子,可直接调控糖酵解和脂肪酸生成相关基因的表达,在细胞代谢与能量平衡中发挥重要作用。细胞代谢改变是肿瘤的重要特征之一,为肿瘤细胞生长及恶性进展创造了有利条件。近年来,研究发现,Mondo蛋白在肿瘤细胞糖酵解、脂肪酸合成和谷氨酰胺利用等代谢通路中发挥着重要作用,而且Mondo蛋白调控肿瘤细胞的代谢,其在肿瘤细胞生长、增殖和侵袭等过程中的作用值得肿瘤研究者关注。因此,更好地认识Mondo蛋白调控肿瘤细胞代谢的机制,将为癌症的治疗提供新的方向。本文对Mondo蛋白家族成员的分子特征、表达调控、组织特异性功能及其在肿瘤代谢重编程和细胞增殖中的最新研究进行综述,为肿瘤的防治提供新思路。The Mondo protein family, as transcription regulators, include two members: MondoA and ChREBP(MondoB), which are key regulators for glucose-mediated gene transcription that can directly regulate the expression of genes related to glycolysis and lipogenesis, and play an important role in cell metabolism and energy balance. Cellular metabolic alteration is one of the important characteristics of tumors, and creates favorable conditions for tumor cell growth and malignant progression. Recent studies have shown that Mondo proteins played important roles in metabolic pathways such as glycolysis, fatty acid synthesis, and glutamine utilization in tumor cells. And the role of Mondo proteins in the growth, proliferation and invasion of tumor cells by regulating the metabolism of tumor cells is worth of cancer researchers’ attention. Further understanding of the mechanism that Mondo proteins regulate tumor metabolism will provide new directions for the treatment of cancer. This paper reviews the molecular characteristics, expression regulation, tissuespecific function of Mondo protein family members and their latest research in metabolic reprogramming and proliferation of tumor cells, which may provide novel ideas for the prevention and treatment of and tumors.

关 键 词：MondoA CHREBP 代谢重编程 肿瘤代谢调控 

分 类 号：R730.2[医药卫生—肿瘤]