IL-1RN基因多态性与消化性溃疡发病相关性及机制分析  

Correlation analysis and mechanism of IL-1RN gene polymorphism and peptic ulcer

作　　者：魏小娟[1] 郭艳 高琦[1] WEI Xiao-juan;GUO Yan;GAO Qi(Department of Gastroenterology, Xinxiang Central Hospital, Xinxiang 453000,China)

机构地区：[1]新乡市中心医院消化内科,新乡453000

出　　处：《天津医科大学学报》2019年第2期154-157,共4页Journal of Tianjin Medical University

摘　　要：目的:探讨白细胞介素-1受体拮抗剂(IL-1RN)基因多态性与消化性溃疡的相关性。方法:选取2016年1月-2018年1月在我院治疗的消化性溃疡患者180例,其中十二指肠溃疡患者91例(十二指肠溃疡组),胃溃疡患者89例(胃溃疡组),同时选取健康志愿者270例作为对照组,检查IL-1RN基因多态性,采用快速尿素酶测定幽门螺旋杆菌感染情况。结果:十二指肠溃疡组IL-1RN基因型L/2+2/2比例和等位基因2比例分别为50.55%和29.67%,明显高于胃溃疡组和对照组(P<0.05);十二指肠溃疡组幽门螺旋杆菌阳性者IL-1RN基因型L/2+2/2比例和等位基因2比例分别为50.15%和29.38%,明显高于胃溃疡组和对照组(P<0.05);胃溃疡组幽门螺旋杆菌阴性者IL-1RN基因型L/2+2/2比例和等位基因2比例分别为62.50%和37.50%,明显高于对照组(P<0.05);十二指肠溃疡幽门螺旋杆菌阴性者等位基因2比例为31.82%,明显高于对照组(P<0.05);十二指肠溃疡组、胃溃疡组不同IL-1RN基因型患者治疗痊愈率比较差异无统计学意义(P>0.05)。结论:IL-1RN基因多态性可能与十二指肠溃疡发病有一定的关系,值得进一步研究。Objective: To investigate the relationship between interleukin -1 receptor antagonist (IL-1RN) gene polymorphism and peptic ulcer. Methods: A total of 180 cases of peptic ulcer in our hospital from January 2016 to January 2018 were selected, including 91 cases of duodenal ulcers (duodenal ulcer group), 89 cases of gastric ulcer (gastric ulcer group), and 270 healthy volunteers as control group. Polymerase chain reaction restriction fragment length polymorphism was used to examine the polymorphism of IL-1RN gene, and rapid urease was used to detect Helicobacter pylori infection. Results:The proportion of IL-1RN genotype L/2+2/2 and the ratio of allele 2 in the duodenal ulcer group were 50.55% and 29.67%, respectively,which were significantly higher than those in the gastric ulcer group and the control group (P<0.05);The proportion of IL-1RN genotype L/2+2/2 and the 2 allele ratio of the Helicobacter pylori positive in the duodenal ulcer group were 50.15% and 29.38%, which were significantly higher than those in the gastric ulcer group and the control group (P < 0.05);The proportion of IL-1RN genotype L/2+2/2 and allele 2 ratio of Helicobacter pylori negative patients in gastric ulcer group were 62.50% and 37.50%, which were significantly higher than those of control group (P< 0.05);The proportion of allele 2 in Helicobacter pylori negative duodenal ulcer was 31.82%, which was significantly higher than that in the control group(P < 0.05);There was no significant difference in the cure rates of IL-1RN genotypes between the duodenal ulcer group and the gastric ulcer group(P>0.05). Conclusion:The polymorphism of IL-1RN gene may be related to the incidence of duodenal ulcer, and is worth further study.

关 键 词：白细胞介素-1受体拮抗剂 基因多态性 十二指肠溃疡 胃溃疡 

分 类 号：R573.1[医药卫生—消化系统]