长春地区幽门螺杆菌分离株对常用抗菌药物耐药性的分析  

Analysis of Antibiotic Resistance of Helicobacter pylori Isolates in Changchun Area

作　　者：范聪聪[1] 赵春燕[1] 江海洋[1] 铁丹丹 赵亚楠[1] 王丽波 FAN Congcong;ZHAO Chunyan;JIANG Haiyang;TIE Dandan;ZHAO Yanan;WANG Libo(Department of Pathogen Biology,College of Basic Medical Sciences,Jilin University,Changchun 130021;Department of Pediatric Gastroenterology,the First Hospital of Jilin University,Changchun)

机构地区：[1]吉林大学基础医学院病原生物学系,130021 [2]吉林大学白求恩第一医院小儿消化内科

出　　处：《胃肠病学》2019年第3期169-172,共4页Chinese Journal of Gastroenterology

基　　金：吉林省科技发展计划资助项目(20170204051SF)

摘　　要：背景:由于临床上抗菌药物的不合理使用,幽门螺杆菌(Hp)的耐药率呈逐年上升的趋势。不同地区的Hp耐药率存在巨大差异。目的:分析长春地区Hp对七种常用抗菌药物的耐药情况,为临床上选择抗菌药物根除Hp感染提供一定的理论指导。方法:收集2014年9月—2017年10月吉林大学白求恩第一医院的298例行胃镜检查患者的黏膜标本,分离并鉴定Hp,并用琼脂稀释法对Hp进行药敏试验。结果:从298例胃黏膜标本中成功分离出69株Hp菌株,阳性率为23. 1%。69株菌株中,克拉霉素的耐药率最高(52. 2%),阿莫西林的耐药率最低(5. 8%)。17株(24. 6%)菌株对七种抗菌药物均敏感,16株(23. 2%)菌株对一种抗菌药物耐药,36株(52. 2%)菌株对两种及以上抗菌药物耐药。结论:本地区Hp对克拉霉素、硝唑类药物均有较高的耐药性,推荐阿莫西林作为根除Hp感染的药物。Background:Due to unrational use of antibiotics in clinical practice,the resistance rate of Helicobacter pylori(Hp)has increased year by year.The drug resistance rate is different in different regions.Aims:To investigate the resistance of Hp to seven commonly used antibiotics in Changchun area,and provide the theoretical guidance for clinical treatment of Hp infection.Methods:The gastric mucosal specimens of 298 patients undergone gastroscopy from Sept.2014 to Oct.2017 at the First Hospital of Jilin University were collected.Hp was isolated and identified.The antibiotic sensitivity of Hp was detected by agar dilution method.Results:A total of 69 Hp strains were successfully isolated from 298 gastric mucosal specimens,the isolation rate was 23.1%.The susceptibility test results showed that the resistance rate of clarithromycin was the highest among the 69 strains(52.2%),the lowest was the resistance rate to amoxicillin(5.8%).Seventeen(24.6%)strains were sensitive to the seven antibiotics,16(23.2%)strains were resistant to one antibiotic,and 36(52.2%)strains were resistant to more than two antibiotics.Conclusions:Hp in this region is highly resistant to clarithromycin and nitrooxazoles.Amoxicillin can be recommended as a treatment for eradication of Hp infection.

关 键 词：幽门螺杆菌 抗菌药 耐药性 微生物敏感性试验 

分 类 号：R573[医药卫生—消化系统]