TACE联合三维适形放疗治疗原发性肝癌的效果及对免疫功能的影响  

Effect of TACE combined with three dimensional conformal radiotherapy in the treatment of primary hepatocellular carcinoma and its influence on immune function

作　　者：刘海涛[1] 马晓萍 郭亮[1] LIU Hai-tao;MA Xiao-ping;GUO Liang(Thoracic Neoplasms Department, Xi'an Electric Power Center Hospital, Xi'an 710032;Genetic Laboratory,Northwest Women's and Children's Hospital, Xi'an 710000, China)

机构地区：[1]西安电力中心医院普胸肿瘤外科,陕西西安710032 [2]西北妇女儿童医院遗传室,陕西西安710000

出　　处：《临床医学研究与实践》2019年第10期17-18,22,共3页Clinical Research and Practice

摘　　要：目的分析肝动脉化疗栓塞术(TACE)联合三维适形放疗(3-DCRT)治疗原发性肝癌的效果及对免疫功能的影响。方法选取我院收治的80例原发性肝癌患者作为研究对象,随机将其分为对照组和观察组,各40例。对照组行TACE治疗,观察组先进行TACE治疗2个疗程,再行3-DCRT治疗,比较两组患者的临床疗效、不良反应发生情况及T淋巴细胞亚群水平。结果观察组的治疗总有效率为82.5%,显著高于对照组的57.5%(P<0.05);观察组的不良反应总发生率为32.5%,显著低于对照组的90.0%(P<0.05);治疗后,观察组CD3+、CD4+水平均显著高于对照组,但CD8+水平低于对照组(P<0.05)。结论对原发性肝癌患者行TACE联合3-DCRT治疗,可改善患者免疫功能,减少不良反应发生情况,提高生存质量,值得临床推广。Objective To analyze the effect of transcatheter arterial chemoembolization (TACE) combined with three dimensional conformal radiotherapy (3-DCRT) in the treatment of primary hepatocellular carcinoma and its influence on immune function. Methods A total of 80 patients with primary hepatocellular carcinoma were selected as the study objects and randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with TACE, and the observation group was treated with 3-DCRT after two courses of TACE. The clinical efficacy, adverse reactions and levels of T lymphocyte subsets were compared between the two groups. Results The total effective rate of treatment in the observation group was 82.5%, which was significantly higher than 57.5% of the control group (P<0.05). The total incidence of adverse reactions in the observation group was 32.5%, which was significantly lower than 90.0% of the control group (P<0.05). After treatment, the levels of CD3+ and CD4+ in the observation group were significantly higher than those of the control group, but the level of CD8+ was lower than that of the control group (P<0.05). Conclusion TACE combined with 3-DCRT can improve the immune function, reduce the occurrence of adverse reactions and improve the quality of life in patients with primary hepatocellular carcinoma, which is worthy of clinical promotion.

关 键 词：TACE 三维适行放疗 原发性肝癌 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]