高尿酸血症对颅内动脉粥样硬化的影响  

Influence of hyperuricemia on intracranial atherosclerosis

作　　者：李佳[1] 徐秋焕[1] 陈涛[1] 杨海燕[1] LI Jia;XU Qiu-huan;CHEN Tao;YANG Hai-yan(Department of Endocrinology, First People's Hospital of Zaoyang City, Zaoyang, Hubei, 441200, China)

机构地区：[1]枣阳市第一人民医院内分泌科,湖北枣阳441200

出　　处：《心血管康复医学杂志》2019年第2期165-169,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:分析并探讨高尿酸血症对颅内动脉粥样硬化的影响。方法:选择2014年5月至2016年7月我院收治的250例非心源性脑梗死患者为研究对象,进行数字减影血管造影检查。根据血尿酸(SUA)水平,患者被分为高尿酸血症组(84例)和正常尿酸组(166例),比较两组患者的年龄,高血压、冠心病、糖尿病、高脂血症比例,吸烟史和脑梗死复发率,并采用单因素及多因素回归分析动脉粥样硬化性颅内动脉狭窄的影响因素。结果:与正常尿酸组相比,高尿酸血症组的缺血性脑卒中复发率(25.30%比45.24%,P=0.001)显著增高。单因素分析显示,高血压、糖尿病和高尿酸血症是颅内动脉狭窄发生的影响因素(P均=0.001);多因素回归分析显示,高血压、糖尿病、高尿酸血症是动脉粥样硬化性颅内动脉狭窄的独立危险因素(OR=0.960～4.957,P均=0.001)。结论:高尿酸血症是颅内动脉粥样硬化性狭窄的独立危险因素。临床上应加强对高尿酸血症患者的监测以预防颅内动脉粥样硬化。Objective: To analyze and explore influence of hyperuricemia (HUA) on intracranial atherosclerosis. Methods: A total of 250 patients with non-cardiogenic cerebral infarction treated in our hospital from May 2014 to Jul 2016 were enrolled.Digital subtraction angiogrophy was performed in all patients. According to level of serum uric acid (SUA), patients were divided into HUA group (n=84) and normal UA group (n=166). Age, percentages of hypertension, coronary heart disease, diabetes mellitus (DM),hyperlipodemia, smoking history and recurrence rate of cerebral infarction were compared between two groups, and influencing factors of atherosclerotic intracranial artery stenosis were analyzed using single- and multi-factor regression analysis. Results: Compared with normal UA group, there was significant rise in recurrence rate of ischemic stroke (25.30% vs. 45.24%) in HUA group, P =0.001. Single factor analysis indicated that hypertension, DM and HUA were influencing factors for intracranial artery stenosis, P =0.001 all;multi-factor regression analysis indicated that hypertension, DM and HUA were independent risk factors for atherosclerotic intracranial artery stenosis (OR=0.960~4.957, P =0.001 all). Conclusion: Hyperuricemia is an independent risk factor for intracranial atherosclerotic stenosis. Monitor on HUA patients should be enhanced in clinic in order to prevent intracranial atherosclerosis.

关 键 词：颅内动脉硬化 高尿酸血症 危险因素 

分 类 号：R743.109[医药卫生—神经病学与精神病学]