血清白蛋白、胆碱酯酶及凝血酶原活动度对病毒性肝炎肝硬化的诊断价值  

Value of the serum albumin,cholinesterase and prothrombin activity in the diagnosis of viral hepatitis cirrhosis

作　　者：薛永举[1] 杨丽[1] 朱玉[1] 郑海伦[1] 李大鹏[1] XUE Yong-ju;YANG Li;ZHU Yu;ZHENG Hai-lun;LI Da-peng(Department of Gastroenterology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院消化科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2019年第3期306-308,313,共4页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究项目(KJ2015A177)

摘　　要：目的:探讨血清白蛋白(ALB)、胆碱酯酶(CHE)、凝血酶原活动度(PTA)检测在病毒性肝炎肝硬化诊断中的价值。方法:选取病毒性肝炎肝硬化病人63例(肝硬化组),病毒性肝炎病人60例(肝炎组),同时选取健康体检者60名作为对照组,检测各组ALB、CHE、PTA水平。结果:肝硬化组ALB、CHE和PTA明显低于肝炎组和对照组(P<0.01);肝硬化组Child-pugh C级病人ALB、CHE和PTA明显低于Child-pugh B级和Child-pugh A级病人(P<0.05～P<0.01);ALB、CHE和PTA诊断病毒性肝炎肝硬化的ROC曲线下面积分别为0.835、0.897和0.746,截断值分别为31.41 g/L、3 785.41 U/L和36.59%时,灵敏度分别为73.30%、85.00%和93.30%,特异度分别为81.00%、79.40%和44.44%。结论:病毒性肝炎肝硬化病人ALB、CHE、PTA水平明显降低,可反映病人Child-pugh分级情况,同时具有一定的诊断价值。Objective: To investigate the value of serum albumin(ALB),cholinesterase(CHE) and prothrombin activity(PTA) in the diagnosis of viral hepatitis cirrhosis. Methods: Sixty-three viral hepatitis cirrhosis patients,60 viral hepatitis patients and 60 healthy volunteers were divided into the cirrhosis group,hepatitis group and control group,respectively.The levels of ALB,CHE and PTA were detected in three groups. Results: The levels of ALB,CHE and PTA in cirrhosis group were significantly lower than those in hepatitis group and control group( P <0.01).The levels of ALB,CHE and PTA in Child-pugh C patients were significantly lower than those in Child-pugh B and A in cirrhosis group( P <0.05 to P <0.01).The areas under the ROC curve of ALB,CHE and PTA in diagnosing viral hepatitis cirrhosis were 0.835,0.897 and 0.746,respectively;the cut-off values of those were 31.41g/L,3 785.41 U/L and 36.59%,respectively;the sensitivity of those were 73.30%,85.00% and 93.30%,respectively,and the specificities of whose were 81.00%,79.40% and 44.44%,respectively. Conclusions: The levels of ALB,CHE and PTA in patients with viral hepatitis cirrhosis significantly decrease,which can reflect the classification of Child-pugh,and has certain diagnostic value.

关 键 词：病毒性肝炎肝硬化 白蛋白 胆碱酯酶 凝血酶源活动度 CHILD-PUGH分级 

分 类 号：R575[医药卫生—消化系统]