肝细胞癌(HCC)门静脉癌栓(PVTT)形成的分子机制研究进展  

Research progresses in the molecular mechanism of the portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC)

作　　者：伊陈禾 杨鑫 王翔宇[1,2] 朱迎 李建华 许达[1,2] 贾户亮 陈进宏[1,2] YI Chen-he;YANG Xing;WANG Xiang-yu;ZHU Ying;LI Jian-hua;XU Da;JIA Hu-liang;CHEN Jin-hong(Department of General Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China;Cancer Metastasis Institute,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院普外科,上海200040 [2]复旦大学肿瘤转移研究所,上海200040

出　　处：《复旦学报（医学版）》2019年第2期261-266,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金面上项目(81672365)~~

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,预后较差。HCC合并门静脉癌栓(portal vein tumor thrombus,PVTT)是影响患者预后的重要危险因素之一,寻找PVTT的有效干预措施对于改善预后具有重要意义。本文从肿瘤细胞自身改变及微环境对肿瘤细胞的影响这两个方面对PVTT形成的分子机制进行综述。Hepatocellular carcinoma(HCC)is one of the most common malignant tumors with poor prognosis in the world.HCC combined with portal vein tumor thrombus(PVTT)is one of the important risk factors affecting the prognosis of patients with liver cancer.Therefore,to explore the effective interventions for PVTT is of great significance to improve the prognosis.In this paper,the molecular mechanisms of PVTT formation are reviewed in the aspects of tumor self-changes and tumor micro-environmental effects.

关 键 词：肝细胞癌(HCC) 门静脉癌栓(PVTT) 分子机制 

分 类 号：R735.7[医药卫生—肿瘤]