细胞因子IL-2、IL-10与高危型HPV感染和宫颈癌关系的研究进展  

Interactions between IL-2,IL-10 and High Risk Human Papillomavirus with Cervical Cancer

作　　者：朱若熙 赵卫红[1] 郝敏[1] ZHU Ruo-xi;ZHAO Wei-hong;HAO Min(Department of Obstetrics and Gynecology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学附属第二医院妇产科,太原030001

出　　处：《国际妇产科学杂志》2019年第2期125-128,133,共5页Journal of International Obstetrics and Gynecology

基　　金：国家卫计委公益性行业科研专项(201402010);山西省重点研发计划项目(201803D31121);山西省自然科学基金面上项目(201601D011086);山西省卫计委科研课题面上项目(2018GW04;2015038);山西省卫计委科研专项(2017056)

摘　　要：宫颈上皮内瘤变与宫颈癌关系密切,是宫颈癌癌前病变的统称,高危型人乳头瘤病毒(HR-HPV)感染是宫颈癌和癌前病变的最重要原因。机体通过增强抗感染免疫和抗肿瘤免疫,可使绝大多数妇女清除病毒和病变细胞,防止宫颈癌的发生。免疫细胞及其分泌的细胞因子在其中发挥了重要作用。细胞因子白细胞介素2(IL-2)、IL-10是由免疫原或其他因子刺激免疫细胞后所产生并分泌的低分子质量的可溶性蛋白质,且与受体的亲和力极高,为其发挥生物学效应提供了结构基础。IL-2、IL-10参与机体的细胞免疫和体液免疫,在宫颈病变的发生、发展中起到了重要的调控作用。但其在宫颈癌和癌前病变中发挥的具体作用及作用机制还不明确,尚存争议。本文综合相关文献报道,对细胞因子IL-2、IL-10与HR-HPV感染和宫颈癌的关系进行综述。As the collective name for precancerous lesions of cervical cancer,cervical intraepithelial neoplasia is closely related to cervical cancer. High-risk human papillomavirus (HR-HPV) infection is the most important cause of cervical cancer and precancerous lesions. By enhancing anti-infective immunity and anti-tumor immunity,most of the women can eliminate virus and diseased cells and prevent cervical cancer. Immune cells and their secreted cytokines play an important role in this. The cytokines IL-2 and IL-10 are low-molecular-weight soluble proteins produced and secreted by immune cells stimulated by immunogens or other factors,which have high affinity with receptors and participate in cellular immunity and humoral immunity of the body. IL-2 and IL-10 play an important role in the pathogenesis and development of cervical lesions,but its specific role and mechanism in cervical cancer and precancerous lesions are still unclear and controversial. This article summarizes the related literature reports and try to illustrate the relationship between cytokines IL-2,IL-10 with HR-HPV infection as well as cervical cancer.

关 键 词：宫颈肿瘤 宫颈上皮内瘤样病变 乳头状瘤病毒科 白细胞介素2 白细胞介素10 

分 类 号：R737.33[医药卫生—肿瘤]