Mda-9/Syntenin在肿瘤进展中的作用研究进展  

Research progress on the role of Mda-9/Syntenin in cancer progression

作　　者：周菊兰 周中银[1] ZHOU Julan;ZHOU Zhongyin(Department of Gastroenterology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Digestive System Disease,Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《疑难病杂志》2019年第4期424-427,432,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：湖北省科学技术计划资助项目(2015BKB013);湖北省自然科学基金资助项目(2013CHB025)

摘　　要：Mda-9/Syntenin是含有2个PDZ结构域的支架蛋白,研究表明其能通过多种途径,经相应的信号转导通路在肿瘤细胞的增殖、侵袭和迁移以及肿瘤血管形成的过程中发挥重要作用。Syntenin主要通过2个PDZ结构域实现其功能,然而,其N-端结构域和C-端结构域对整个蛋白的稳定性发挥重要作用。文章旨在综述Mda-9/Syntenin在肿瘤进展中的作用及相关研究进展。Mda-9/Syntenin is a scaffold protein with two PDZ domains.Studies have shown that Mda-9/Syntenin can play an important role in the proliferation,invasion and migration of cancer cells and angiogenesis of tumors through various signaling pathways.Syntenin functions mainly through two PDZ domains.However,its N-terminal domain and C-terminal domain play an important role in the stability of the whole protein.The purpose of this article is to review the role of Mda-9/Syntenin in cancer progression and related research progress.

关 键 词：Mda-9/Syntenin 整合素 EGFR c-Src-FAK复合物 

分 类 号：R730.2[医药卫生—肿瘤]