93例包含脊索瘤的双原发恶性肿瘤临床分析  

Clinical Analysis of 93 Cases of Double Primary Malignant Tumors Involving Chordoma

作　　者：马振 吴鑫 李延坤 翟凯 田云虎[3] MA Zhen;WU Xin;LI Yan-kun;ZHAI Kai;TIAN Yun-hu(Graduate School of Weifang Medical University ,Weifang 261000, China;Department of Oncology, First Affiliated Hospital of China Medical University ,Shenyang 110001,China;Department of Spine Surgery, Affiliated Hospital of Weifang Medical University , Weifang 261000, China)

机构地区：[1]潍坊医学院研究生院,潍坊261000 [2]中国医科大学附属第一医院肿瘤科,沈阳110001 [3]潍坊医学院附属医院脊柱外科,潍坊261000

出　　处：《科学技术与工程》2019年第11期49-54,共6页Science Technology and Engineering

摘　　要：为研究包含脊索瘤的双原发恶性肿瘤的临床特征及预后,评估生存相关的预后因素,通过回顾性分析2004～2015年SEER数据库中临床数据的方法研究了93例合并脊索瘤的双原发恶性肿瘤患者的临床资料。结果表明:93例病例中,双原发脊索瘤的发病率为10. 7%,高发的其他原发恶性肿瘤(非脊索瘤)为:前列腺癌、恶性黑色素瘤、甲状腺癌;脊索瘤好发部位为骨盆、骶尾骨、脊椎、颅骨; A组中双原发肿瘤中位间隔时间为28个月(0～88个月),B组双原发肿瘤中位间隔时间为48个月(0～434个月),两组间隔时间差异有统计学意义(P=0. 009);合并脊索瘤的双原发恶性肿瘤多发于老年男性(男∶女=1. 74∶1),异时瘤组多见(3. 43∶1),同时瘤组(C组)及异时瘤组(D组)在年龄、种族、N、M分期等方面差异无统计学意义(P>0. 05)。在性别、T分期、手术与否等方面差异有统计学意义(P≤0. 05);异时瘤组(D组)及手术组5年生存率、中位生存期较佳(P <0. 05)。可见在包含脊索瘤的双原发恶性肿瘤中,最高发的其他恶性肿瘤为前列腺癌,脊索瘤更好发于骨盆及骶尾部,异时瘤组(D组)及手术组的预后更好。In order to study the clinical features and prognosis of double primary malignant tumors including chordoma, and to evaluate survival-related prognostic factors, Clinical data in the SEER database from 2004 to 2015 was used to investigate the clinical data of 93 patients with double primary malignant tumors with chordoma. The results show that in 93 cases,the incidence of double primary chordoma is 10.7%, and other primary malignant tumors(non-chondroma)were prostate cancer, malignant melanoma, thyroid cancer;The prediletion sites of chordoma were pelvis, appendix, spine, skull;The median interval between the two primary tumors in group A was 28 months (0~88 months), and the median interval between the two primary tumors in group B was 48 months ( 0~ 434 months). The difference between the two groups was statistically significant ( P =0.009);Double primary malignant chordoma Tumors were more common in older men (male ∶female=1.74 ∶1),the metachronous tumor group (3.43 ∶1), and Simultaneous dual primary malignant tumor group (group C) and Metachronous double primary malignant tumor group (group D) were no significant difference in age, ethnicity, N,M staging ( P >0.05), and significant difference in gender, T stage, surgery or not ( P ≤0.05);the group D and operation group were better in the 5-year survival rate and median survival time( P <0.05). It is concluded that in the double primary malignant tumors involving chordoma, the highest incidence of the other malignant tumors and chordoma’s sites are prostate cancer and pelvis and appendix respectively, and the prognosis is better in the metachronous tumor group (group D) and the surgery group.

关 键 词：脊索瘤 多原发肿瘤 临床特征 预后 

分 类 号：R738[医药卫生—肿瘤]