哺乳动物雷帕霉素靶蛋白与自噬通路在阿尔茨海默病中的研究进展  

Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer’s Disease

作　　者：常艳芳 胡为民[1] CHANG Yanfang;HU Weimi(Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院神经内科

出　　处：《中国医学科学院学报》2019年第2期248-255,共8页Acta Academiae Medicinae Sinicae

摘　　要：哺乳动物雷帕霉素靶蛋白(mTOR)是一种重要的丝氨酸/苏氨酸蛋白激酶,参与调节蛋白质合成和降解、细胞骨架形成并影响寿命。自噬是维持细胞内稳态所必需的分解代谢过程,自噬的存在对于细胞存活至关重要,而mTOR是调节自噬过程的主要因子。阿尔茨海默病是老年人群中常见的中枢神经系统退行性疾病,大量证据表明,mTOR和自噬信号通路的紊乱与阿尔茨海默病密切相关。本文就mTOR、自噬通路与阿尔茨海默病的相关机制以及靶向此通路的阿尔茨海默病治疗药物做一综述。The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis and degradation,cytoskeletal formation,and cell longevity.Autophagy,a catabolic process necessary for the maintenance of intracellular homeostasis,is essential for cell survival,whereas mTOR is the crucial regulator of autophagy.Alzheimer ’s disease(AD)is the most common cause of progressive dementia in the elderly.It has been shown that disorders of mTOR and autophagy signaling pathways are closely related to AD.In the present review,we describe the regulatory roles of mTOR signaling and autophagy pathway in AD brain and introduce drugs for AD acting via modulation of autophagy and mTOR.

关 键 词：哺乳动物雷帕霉素靶蛋白 自噬 阿尔茨海默病 神经退行性疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]