脑卒中患者血清PARK7及ADMA水平与神经功能缺损的关系  

Relationship between serum PARK7,ADMA and neurological deficit in stroke patients

作　　者：曹康 张永全[2] 蔡碧清 胡洒洒 潘珠娣 CAO Kang;ZHANG Yongquan;CAI Biqing;HU Sasa;PAN Zhudi(Guangxi University of Traditional Chinese Medicine,Nanning530000,China;Department of Neurology,Ruikang Hospital,Guangxi University of Traditional Chinese Medicine,Nanning 530000,China)

机构地区：[1]广西中医药大学,广西南宁530000 [2]广西中医药大学附属瑞康医院神经内科二区,广西南宁530000

出　　处：《中国实用神经疾病杂志》2019年第3期260-266,共7页Chinese Journal of Practical Nervous Diseases

基　　金：广西卫生厅中医药管理局自筹课题(编号:GZZC14-31);广西教育厅自筹课题(编号:KY2015LX160)

摘　　要：目的研究脑卒中患者血清人帕金森蛋白7(PARK7)、非对称二甲基精氨酸(ADMA)水平与神经功能缺损程度的关系。方法 2017-01-01—2018-01-01至广西中医药大学附属瑞康医院就诊的脑卒中随机选取患者82例,同时随机选择非脑卒中患者82例为对照组。对卒中患者组进行量化评分分为轻、中及重度损害组各48例、20例、14例。所有卒中组患者入院后均给予脱水、降颅压、保持呼吸道通畅及预防并发症等对症处理,分别测定2组血清PARK7、ADMA水平作以参考。结果对比2组血清PARK7水平,轻度、中度及重度损害组分别为(20.19±4.21)μg/L、(27.68±4.53)μg/L及(33.74±5.27)μg/L,均明显高于对照组,差异有统计学意义(P<0.05),且3组间对比差异有统计学意义(P<0.05);对比2组血清ADMA水平,发现轻、中及重度损害组分别为(50.24±10.28)μmol/L、(74.72±11.84)μmol/L及(91.71±10.49)μmol/L,均明显高于对照组,2组比较差异有统计学意义(P<0.05)。Speaman等级相关和Pearson相关性分析显示,2组血清学数据与脑卒中患者神经功能相关评分严重程度呈正相关变化。即神经功能缺损越严重,其血清PARK7、ADMA水平亦越高(r_(PARK7)=0.996 7,P_(PARK7)=0.003 3;r_(ADMA)=0.999 7,P_(ADMA)=0.000 3),差异有统计学意义(P<0.05)。结论脑卒中患者通常表现为不同程度的神经功能缺损,其血清PARK7、ADMA水平亦呈正相关变化,或可为脑卒中的早期诊疗提供理论依据,对不同程度脑卒中转归的判断具有一定指导作用,有利于治疗及病情评估。Objective To study the relationship between serum human Parkinson's protein 7 (PARK7),asymmetric dimethylarginine ( ADMA) levels and neurological deficits in stroke patients. Methods A total of 82 stroke patients were randomly selected in the Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine.82 patients with non stroke were randomly selected as the control group.The quantitative scores of the stroke patients were divided into 48 cases of mild injury group,20 cases of moderate damage group and 14 cases of severe damage group.All stroke patients were treated with dehydration,intracranial pressure reduction, airway patency and prevention of complications after admission.The levels of PARK7 and ADMA in serum were determined for reference. Results Comparing the levels of PARK7 in serum,the patients with mild,moderate and severe damage were found to be (20.19±4.21)μg/L,(27.68±4.53)μg/L and (33.74±5.27)μg/L,respectively, which were significantly higher than the control group.The difference was statistically significant( P <0.05),and the difference between the three groups was statistically significant( P <0.05).Compared with the serum ADMA level,the light,moderate and severe damage groups were found to be (50.24±10.28)μmol/L,(74.72±11.84)μmol/L and (91.71±10.49)μmol/L were significantly higher than the control group,and there were significant differences between the two groups ( P <0.05).Speaman rank correlation and Pearson correlation analysis showed that there was a positive correlation between the serological data of the two groups and the severity of neurological function related score in stroke patients.Namely,the more severe the neurological impairment was,the higher the serum PARK7 and ADMA levels were (r PARK7 =0.996 7,P PARK7 =0.003 3;r ADMA =0.999 7,P ADMA =0.000 3),the difference was statistically significant( P <0.05). Conclusion When a stroke accident occurs,it usually shows different degrees of neurological deficit.The serum levels of PARK7 and ADMA are also posi

关 键 词：脑卒中 人帕金森蛋白7 DJ1蛋白质 非对称二甲基精氨酸 血清 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]