白藜芦醇多靶点治疗阿兹海默病的研究进展  

Advances in research on multi-target resveratrol treatment of Alzheimer's disease

作　　者：王丹鹏 WANG Danpeng(The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院,四川成都610075

出　　处：《中国实用神经疾病杂志》2019年第3期343-348,共6页Chinese Journal of Practical Nervous Diseases

摘　　要：近年来针对阿兹海默病■淀粉样蛋白(A■)、■分泌酶(BACE)等靶点新药研发的临床试验相继失败,而阿兹海默症是多因素综合长期进行性损害脑神经,寻找正确而有效的抗阿兹海默病药物以及联合用药是未来研究的重要方向。白藜芦醇的研究近年来发展迅猛,其具有天然的抗氧化,抗炎特性在针对阿兹海默症有无症状前期的治疗有较好的发展前景。近年来针对白藜芦醇改良的衍生物及与其他治疗方法的联合针对蛰合金属酶,减少A■聚集、降低tau蛋白过度磷酸化、阻断NF-κB通路、诱导沉默信息调节因子1等靶点作用具有显著效果。本文对近年来白藜芦醇及其衍生物的靶点治疗和与其他治疗途径联合作用的研究进展做一综述,为白藜芦醇及其衍生物进一步的发展提供参考。In recent years,clinical trials for the development of new drugs targeting Alzheimer's disease β amyloid (Aβ) and β secretase (BACE) have failed,and Alzheimer's disease is a multi factor comprehensive long term damage.Cranial nerves,finding the right and effective anti Alzheimer's disease and combination drugs is an important direction for future research.The research on resveratrol has developed rapidly in recent years,and its natural antioxidant and anti inflammatory properties have a good development prospect in the treatment of pre symptomatic symptoms of Alzheimer's disease.In recent years,resveratrol modified derivatives and other therapeutic methods have been combined with metalloenzymes to reduce Aβ aggregation,reduce tau hyperphosphorylation,block NF κB pathway,and induce silencing regulator 1 and other targets.The point effect has a significant effect.In this review,recent advances in the treatment of resveratrol and its derivatives with other therapeutic pathways provide a reference for the further development of resveratrol and its derivatives.

关 键 词：白藜芦醇 阿兹海默病 抗炎 抗氧化 白藜芦醇衍生物 

分 类 号：R749.1[医药卫生—神经病学与精神病学]