Study on the packed volume and the void ratio of idealized human red blood cells using a ?nite-discrete element method  

作　　者：Dong XU Chunning JI A.MUNJIZA E.KALIVIOTIS E.AVITAL J.WILLAMS 

机构地区：[1]State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University [2]School of Engineering & Material Science, Queen Mary University of London [3]Faculty of Engineering and Technology, Cyprus University of Technology

出　　处：《Applied Mathematics and Mechanics(English Edition)》2019年第5期737-750,共14页应用数学和力学（英文版）

基　　金：Project supported by the Engineering and Physical Sciences Research Council(EPSRC)Turbulence Consortium Grant(No.EP/G069581/1);the Marie Curie International Incoming Fellowship(No.PIIF-GA-253453)

摘　　要：Numerical simulations are performed to examine the packing behavior of human red blood cells(RBCs). A combined ?nite-discrete element method(FDEM) is utilized, in which the RBCs are modeled as no-friction and no-adhesion solid bodies. The packed volume and the void ratio of a large number of randomly packed RBCs are clari?ed,and the effects of the RBC shape, the mesh size, the cell number, and the container size are investigated. The results show that the packed human RBCs with normal shape have a void ratio of 28.45%, which is slightly higher than that of the ?at or thick cells used in this study. Such information is bene?cial to the further understanding on the geometric features of human RBCs and the research on RBC simulations.Numerical simulations are performed to examine the packing behavior of human red blood cells(RBCs). A combined ?nite-discrete element method(FDEM) is utilized, in which the RBCs are modeled as no-friction and no-adhesion solid bodies. The packed volume and the void ratio of a large number of randomly packed RBCs are clari?ed,and the effects of the RBC shape, the mesh size, the cell number, and the container size are investigated. The results show that the packed human RBCs with normal shape have a void ratio of 28.45%, which is slightly higher than that of the ?at or thick cells used in this study. Such information is bene?cial to the further understanding on the geometric features of human RBCs and the research on RBC simulations.

关 键 词：RED BLOOD cell (RBC) VOID ratio packed VOLUME DISCRETE element method 

分 类 号：Q291[生物学—细胞生物学]