血清神经元特异性烯醇化酶/癌胚抗原及胃泌素释放肽前体/癌胚抗原比值在诊断小细胞肺癌中的价值  

Value of serum neuron-specific enolase/carcinoembryonic antigen and pro-gastrin releasing peptide/carcinoembryonic antigen ratio in the diagnosis of small cell lung cancer

作　　者：刘琳 朱立强 赵利[2] LIU Lin;ZHU Liqiang;ZHAO Li(Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002;Department of Clinical Laboratory, Xuzhou Tumor Hospital, Xuzhou Jiangsu 221000, China)

机构地区：[1]徐州医科大学附属医院检验科,江苏徐州221002 [2]徐州市肿瘤医院检验科,江苏徐州221000

出　　处：《临床与病理杂志》2019年第4期776-779,共4页Journal of Clinical and Pathological Research

摘　　要：目的:观察肺癌患者血清中神经元特异性烯醇化酶(neuron-specificenolase,NSE)、癌胚抗原(carcinoembryonicantigen,CEA)、胃泌素释放肽前体(pro-gastrinreleasingpeptide,pro-GRP)的含量,分析NSE/CEA和pro-GRP/CEA在鉴别诊断小细胞肺癌(small cell lung cancer,SCLC)中的应用价值。方法:应用电化学发光法分别检测60例非小细胞肺癌(non-small cell lung cancer,NSCLC;肺鳞癌22例、肺腺癌38例)及45例SCLC患者血清中的NSE,pro-GRP,CEA的含量,并计算NSE/CE A和pro-GRP/CE A。利用ROC曲线确定NSE/CE A和pro-GRP/CE A鉴别诊断SCLC的最佳界值。结果:NSE/CEA值在鉴别SCLC和NSCLC的ROC曲线下面积为0.90,敏感度为88.90%,特异度85.00%,最佳判断值为3.78。pro-GRP/CE A值在鉴别SCLC和其他两种肺癌的ROC曲线下面积为0.94,敏感度为86.70%、特异度91.70%,最佳判断值为28.61。结论:NSE/CEA和pro-GRP/CEA有助于鉴别诊断SCLC和NSCLC,有较高的应用价值。Objective: To evaluate the levels of neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and pro-gastrin releasing peptide (pro-GRP) in the serum of patients with lung cancer and analyze clinical significance of NSE/CEA and pro-GRP/CEA ratio in the differential diagnosis of small cell lung cancer (SCLC). Methods: Forty-five cases with SCLC and 60 patients with non-small cell lung cancer lung cancer (NSCLC), including 22 cases with lung squamous carcinoma and 38 cases with lung adenocarcinoma were selected.The levels of multiple serum tumor markers (NSE, CEA, pro-GRP) in the serum of patients were detected by electrochemiluminescence immunoassay. And the ratio of NSE/CEA, pro-GRP/CEA were calculated. ROC curve was used to evaluate the best value of NSE/CEA and pro-GRP/CEA ratio in the differential diagnosis of SCLC. Results: At the threshold of 3.78, sensitivity and specificity of NSE/CEA as a serologic marker were 88.90% and 85.00%, respectively for distinguish SCLC and NSCLC. ROC curve showed that area under the curve (AUC) was 0.90. At the threshold of 28.61, sensitivity and specificity of pro-GRP/CEA as a serologic marker were 86.70% and 91.70%, respectively for distinguish SCLC and NSCLC. ROC curve showed that AUC was 0.94. Conclusion: Combined examination of multiple serum tumor markers and the NSE/CEA and pro-GRP/CEA ratio can effectively improve the accuracy in the differential diagnosis of SCLC.

关 键 词：小细胞肺癌 神经元特异性烯醇化酶/癌胚抗原 胃泌素释放肽前体/癌胚抗原 肿瘤标志物 鉴别诊断 

分 类 号：R734.2[医药卫生—肿瘤]