原发性皮肤弥漫大B细胞淋巴瘤(腿型)  

A case of primary cutaneous diffuse large B-cell lymphoma,leg type

作　　者：康莉[1] 关羽 刘艳[1] 储小燕[1] 蒋洁瑶[1] 苏彤[1] 顾雪芹 纪超[2] 毕志刚[1] KANG Li;GUAN Yu;LIU Van;CHU Xiao-van;JIANG Jie-yao;SU Tong;GU Xue-qin;JI Chao;Bl Zhi-gang(The Affiliate BenQ Hospital of Nanjing Medical University,Nanjing 210019, China)

机构地区：[1]南京医科大学附属明基医院皮肤科,江苏南京210019 [2]福建医科大学附属第一医院皮肤科,福建福州350000

出　　处：《临床皮肤科杂志》2019年第4期222-225,共4页Journal of Clinical Dermatology

摘　　要：报告1例原发性皮肤弥漫大B细胞淋巴瘤(腿型)。患者男,78岁。左小腿多个暗红色斑块、结节2个月余。左下肢皮损组织病理检查:真皮内弥漫淋巴样细胞浸润,肿瘤细胞体积大,胞质淡染,核大、不规则,异形性明显,有丝分裂象易见。免疫组化:CD3(-)、CD8(-)、CD20(+)、CD79α(+)、B细胞淋巴瘤(Bcl)-2(+)、Bcl-6(+)、多发性骨髓瘤癌基因(MUM)-1(-)、CD10(-)、T细胞内抗原(TIA)(-),Kappa(k)(+)、Lambda(λ)(-)、增殖核抗原(Ki-67)约95%(+)。诊断:原发性皮肤弥漫大B细胞淋巴瘤(腿型)。治疗上给予R-CDOP方案[利妥昔单抗+(环磷酰胺+脂质体多柔比星+长春新碱+泼尼松)]化疗后,左小腿肿块缩小。A case of primary cutaneous diffuse large B-cell lymphoma(leg type) is reported. A 78-year-old man presented with a 2-month history of dark red plaques and nodules on his left lower leg. Histopathologic examination revealed lymphoid infiltration in the dermis. Majority of tumor cells were large with pale cytoplasm and irregular or atypical nuclei and mitotic activity. Immunohistochemistry demonstrated CD20(+), CD79 a(+), Bcl-2(+), Bcl-6(+), Kappa(k)(+), CD3(-), CD8(-), CD10(-),Mum-1(-), TIA(-), Lambda(λ)(-) and Ki-67(95%+). The patient was diagnosed with primary cutaneous diffuse large B-cell lymphoma(leg type). After R-CDOP chemotherapy, the tumor became smaller.

关 键 词：弥漫大B细胞淋巴瘤 皮肤 原发性 

分 类 号：R733.1[医药卫生—肿瘤]