PRMT2β suppresses autophagy and glycolysis pathway in human breast cancer MCF-7 cell lines  

作　　者：Yajun Chenx Xianpeng Dai Yao Yao Jing Wang Xinzhi Yang Yunsheng Zhang Jing Yang Renxian Cao Gebo Wen Jing Zhong 

机构地区：[1]Institute of Clinical Medicine,The First Affiliated Hospital of University of South China,Hengyang 421001,China [2]Department of Metabolism and Endocrinology,The Second Affiliated Hospital of University of South China,Hengyang 421001,China [3]Department of General Surgery,The Second Affiliated Hospital of University of South China,Hengyang 421001,China [4]Institute of Clinical Medicine,The Second Affiliated Hospital of University of South China,Hengyang 421001,China [5]Department of Metabolism and Endocrinology,The First Affiliated Hospital of University of South China,Hengyang 421001,China

出　　处：《Acta Biochimica et Biophysica Sinica》2019年第3期335-337,共3页生物化学与生物物理学报（英文版）

基　　金：the grants from the National Natural Science Foundation of China(Nos.81773294,81472608 and 31200573);the project of Education Department of Hunan Province(Nos.16A189 and 15C1204);the Natural Science Foundation of Hunan Province(No.13JJ6051);the Chuanshan Talent Project of the University of South China(No.CS2018-3-35).

摘　　要：Autophagy as a novel therapeutic target can inhibit or increase treatment efficacy in various types of breast cancer in a cell-type-dependent manner [1,2].Several studies have revealed that the coordination between Akt and the glycolytic pathway plays an indispensable role in mediating autophagy and caspase-dependent apoptosis,suggesting that a new regulatory mechanism for the process [3,4].Protein arginine N-methyltransferases(PRMTs)are eukaryotic enzymes that catalyze the transfer of methyl groups from S-adenosylmethionine to arginine residues of numerous PRMT substrates [5,6].PRMT2(also known as HRMT1L1)belongs to the arginine methyltransferase family [7].PRMT2β is a novel PRMT2 splice variant isolated from breast cancer cell [8].It occurs at the 3′ end of the PRMT2,resulting in loss of exons 7–9 and downstream frame-shifting [9].PRMT2β possesses 83 new amino acids at the C-terminus and its size is 301 amino acids.Our previous study reported that PRMT2β has potential antitumor effect by suppressing cyclin D1 expression [10].However,little is known about whether PRMT2β could regulate autophagy and glycolysis of MCF-7 cells.

关 键 词：MCF-7 apoptosis expression treatment CYCLIN can Akt its 

分 类 号：Q74[生物学—分子生物学]