胃间质瘤患者术前C反应蛋白/白蛋白比值与NIH分级相关性的研究  

Correlation between preoperative C-reactive protein/albumin ratio and NIH risk classification in patients with gastric stromal tumor

作　　者：方仕旭 曾玉剑[1] 林彬 张同[1] 罗华友[1] FANG Shixu;ZENG Yujian;LIN Bin;ZHANG Tong;LUO Huayou(Department of Gastroenterology and Hernia Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,P.R.China;The First Clinical College of Kunming Medical University,Kunming 650032,P.R.China)

机构地区：[1]昆明医科大学第一附属医院胃肠与疝外科,昆明650032 [2]昆明医科大学第一临床学院,昆明650032

出　　处：《中国普外基础与临床杂志》2019年第4期428-431,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：云南省卫生科技计划项目(项目编号:2017NS001)

摘　　要：目的探讨胃间质瘤患者术前C反应蛋白(CRP)/白蛋白(albumin)比值(CAR)与美国国立卫生研究院(NIH)分级的关系。方法回顾性收集2010年2月至2016年11月期间昆明医科大学第一附属医院收治的108例胃间质瘤患者的临床资料,以CAR的中位数为临界值,将患者分为高CAR值组(CAR>0.048)和低CAR值组(CAR≤0.048)。观察比较高、低CAR组的一般临床病理学特征及生存状态。结果高CAR组及低CAR组患者的肿瘤直径、核分裂象和NIH分级比较差异均有统计学意义(P<0.05),与低CAR组相比,高CAR组的肿瘤直径更大、核分裂象更高、NIH分级越高。生存分析结果显示:低CAR组患者的预后较高CAR组更好(χ2=15.152,P<0.001)。结论 CAR与胃间质瘤的肿瘤直径、核分裂象和NIH分级密切相关,可作为评估胃间质瘤恶性程度的指标,有望在临床上作为NIH危险度分级评估及预后的重要参考因素。Objective To investigate the relationship between preoperative C-reactive protein(CRP)/albumin ratio(CAR)and National Institutes of Health(NIH)risk classification in patients with gastric stromal tumors.Methods Clinical data of 108 patients with gastric stromal tumors admitted to the First Affiliated Hospital of Kunming Medical University from February 2010 to November 2016 were retrospectively collected.With the median of CAR as the critical value,patients were divided into high CAR group(CAR>0.048)and low CAR group(CARW0.048).Then observed the general clinicopathological characteristics and survival status of patients w让h higher and lower CAR value.Results There were significant differences in NIH classification,tumor diameter,and mitosis between the high CAR group and low CAR group(P<0.05).Compared with the low CAR group,the tumors in the high CAR group had larger diameter,higher mitotic figure,and higher NIH grade.Survival analysis showed that the prognosis of the low CAR group was better than that of the high CAR group(χ^2=15.152,P<0.001).Conclusions CAR is closely related to the malignant index and NIH risk classification of gastric stromal tumors.It can be used as an index for evaluating the malignant degree of gastric stromal tumors,and辻 is expected to be an important reference factor for clinical NIH risk classification and prognosis.

关 键 词：胃间质瘤 C反应蛋白/白蛋白比值 美国国立卫生研究院分级 

分 类 号：R735.2[医药卫生—肿瘤]