基于空间对齐和轮廓匹配的颈动脉多对比MRI三维配准方法  

Multi-contrast Carotid MRI 3D Registration Method Based on Spatial Alignment and Contour Matching

作　　者：汪晓妍[1] 刘琪琪 黄晓洁 姜娓娓 夏明[1] WANG Xiao-yan;LIU Qi-qi;HUANG Xiao-jie;JIANG Wei-wei;XIA Ming(College of Computer Science and Technology,Zhejiang University of Technology,Hangzhou 310023,China;School of Medicine,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江工业大学计算机科学与技术学院,杭州310023 [2]浙江大学医院,杭州310058

出　　处：《计算机科学》2019年第5期241-246,共6页Computer Science

基　　金：浙江省自然科学基金(LY18F030019;LY18F020030);国家自然科学基金(11302195;61401397;61701442)资助

摘　　要：多对比高分辨率磁共振成像(Magnetic Resonance Imaging,MRI)技术可以无创显示管壁结构和斑块成分,为分析颈动脉粥样硬化斑块提供了一种有效手段。多对比图像中的血管配准是斑块成分识别的关键任务,由此提出一种基于空间位置对齐和内腔轮廓匹配的颈动脉多对比磁共振图像三维配准算法。基于多对比序列图像,采用由粗到细的策略:首先利用图像的物理坐标进行空间位置的层间对齐;然后运用最大类间方差法和活动轮廓模型实现各序列血管内腔的半自动连续分割;最后以内腔轮廓组成的三维点云进行基于改进迭代最近点算法的三维配准。实验结果表明,配准后TOF序列和T_1Gd序列的三维内腔包含率达到92.79%,T_1WI序列和T_1Gd序列的三维内腔包含率达到94.66%,实现了多对比磁共振图像血管的三维精确配准,为后续易损斑块的成分分析奠定了基础。Multi-contrast high-resolution magnetic resonance imaging(MRI)technology can non-invasively display the wall structure and plaque composition,providing an effective method for diagnosis and analysis of carotid atherosclerotic plaque.The registration of vessels in multi-contrast images becomes a critical task for plaque identification.This paper proposed a three-dimensional registration algorithm based on spatial position alignment and lumen contour matching.With multi-contrast carotid MRI,a coarse-to-fine strategy was adopted.Firstly,the physical coordinates are found to perform the spatial alignment.Then,the ostu algorithm and active contour model are used to complete the semi-automatic continuous segmentation of the blood vessel lumens.Finally,the lumen contour point clouds are utilized to perform three-dimensional rigid registration based on an improved iterative closest point algorithm.The results indicate that the three-dimensional average lumen inclusion rate between TOF and T 1Gd sequence reaches 92.79%,and the average lumen inclusion rate between T 1WI and T 1Gd sequence reaches 94.66%.The proposed algorithm achieves three-dimensional accurate registration of multi-contrast MRI,which lays the foundation for the subsequent analysis of vulnerable atherosclerotic plaque.

关 键 词：颈动脉粥样硬化 磁共振图像 多对比 三维配准 易损斑块 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]