细胞穿膜肽在肿瘤研究中的应用  

Research advances in role of cell-penetrating peptides in tumor

作　　者：林芯芮 余婷[1] 杨举伦 LIN Xinrui;YU Ting;YANG Julun(920th Hospital of the Joint Logistics Support Force of PLA, Clinical College of Kunming Medical University, Kunming 650032, Yunnan Province, China;Department of Pathology, 920th Hospital of the Joint Logistics Support Force of PLA, Kunming 650032, Yunnan Province, China)

机构地区：[1]昆明医科大学联勤保障部队第920医院临床学院,云南昆明650032 [2]联勤保障部队第920医院病理科,云南昆明650032

出　　处：《解放军医学院学报》2019年第2期183-185,189,共4页Academic Journal of Chinese PLA Medical School

基　　金：2018云南省科技计划项目重大科技专项(2018ZF009)~~

摘　　要：由于细胞膜的选择透过性,多数大分子物质难以进入细胞内发挥作用。细胞穿膜肽(cell-penetrating peptides,CPPs)可通过共价或非共价连接的方式携带大分子物质进入细胞内,是跨膜转运的有效载体,被广泛用于向细胞内递送蛋白质、脂质体、核苷酸等。本文就基于CPPs的肿瘤治疗和肿瘤分子成像研究已取得的进展进行综述,以期为肿瘤诊治研究提供参考。Due to the selective permeability of cell membranes, it is difficult for many macromolecular substances to enter cells. Cellpenetrating peptides(CPPs), which can carry macromolecular substances into cells by means of covalent coupling or non-covalent complex formation, are effective carriers for the intracellular delivery, and they are widely used to deliver proteins, liposomes and nucleotides into the cells. CPPs-based tumor treatment and tumor molecular imaging studies have made a lot of progresses that are reviewed in this article in order to provide insights for the diagnosis and treatment of tumors.

关 键 词：细胞穿膜肽 肿瘤细胞 肿瘤疫苗 

分 类 号：R730.5[医药卫生—肿瘤]