Negishi交叉偶联反应在药物化学中的应用  

Application of Negishi Cross-coupling in the Synthesis of Bioactive Molecules

作　　者：张庆文[1] ZHANG Qingwen(Division of Medicinal and Process Chemistry, Shanghai Institute of Pharmaceutical Industry,China Institutes of Pharmaceutical Industry, Shanghai 201203)

机构地区：[1]中国医药工业研究总院上海医药工业研究院化学制药部,上海201203

出　　处：《中国医药工业杂志》2019年第4期359-382,共24页Chinese Journal of Pharmaceuticals

基　　金：国家留学基金管理委员会项目(201408310035);上海市国际学术合作交流项目(16430723900)

摘　　要：赢得诺贝尔化学奖殊荣的Negishi交叉偶联反应是构建碳碳键的强有力工具。本文介绍了Negishi反应的基本概况和新近进展,着重以应用实例阐述Negishi反应在药物、候选药物和天然产物等生物活性分子合成中的重要价值,以期促进Negishi反应在学术界和工业界的运用和创新。The Nobel Prize-winning Negishi cross-coupling reaction is a powerful tool for constructing carboncarbon bond. This perspective covers the general aspects and recent advances of this important organic name reaction, with emphasis on its state-of-the-art applications in the synthesis of bioactive molecules such as drugs, drug candidates and natural products, hoping to encourage Negishi reaction implementation and innovation in both academia and industry.

关 键 词：Negishi交叉偶联反应 有机锌试剂 催化剂和配体 药物合成 天然产物合成 

分 类 号：R914.5[医药卫生—药物化学]