膦甲酸钠对高危型人乳头瘤病毒持续感染患者宫颈灌洗液IL-4、IL-12、IFN-γ的调节作用  

Regulatory effect of foscarnet sodium on IL-4,IL-12 and IFN-γin cervical lavage fluid of patients with persistent high-risk human papillomavirus infection

作　　者：刘静[1] 张吟真[1] 陶静[1] 丁维[1] 虞敏[1] Liu Jing;Zhang Yinzhen;Tao Jing;Ding Wei;Yu Min(Department of Gynecology,Changshu Fifth People’s Hospital of Jiangsu,Changshu 215500,China)

机构地区：[1]江苏省常熟市第五人民医院妇科,215500

出　　处：《中国实用医刊》2019年第4期34-37,共4页Chinese Journal of Practical Medicine

基　　金：2014年度苏州市"科技兴卫"青年科技计划项目(KJXW2014044)。

摘　　要：目的探讨膦甲酸钠对高危型人乳头瘤病毒(HPV)持续感染患者宫颈灌洗液白细胞介素-4(IL-4)、白细胞介素-12(IL-12)、干扰素-γ(IFN-γ)的调节作用。方法选择2015年10月至2016年12月常熟市第五人民医院高危型HPV持续感染患者60例,将60例患者随机分为生活方式干预组和膦甲酸钠治疗组,每组30例,选择同期本院体检的健康人员30例作为正常对照组。生活方式干预组给予合理运动、保证睡眠、性生活使用避孕套等治疗,膦甲酸钠治疗组在生活方式干预组的基础上给予膦甲酸钠氯化钠注射液静脉滴注2周,两组均干预3个月.治疗前后均采用酶联免疫吸附法测定所有受试者宫颈灌洗液IL-4、IL-12、IFN-γ水平。结果治疗前生活方式干预组和膦甲酸钠治疗组患者宫颈灌洗液IL-4水平高于正常对照组(P均<0.01),IL-12、IFN-γ水平低于正常对照组(P均<0.01)。生活方式干预组治疗前后宫颈灌洗液IL-4、IL-12、IFN-γ水平比较差异均未见统计学意义(P>0.05)。膦甲酸钠治疗组患者治疗后较治疗前宫颈灌洗液IL-4水平降低(P<0.01),IL-12、IFN-γ水平升高(P均<0.01)。结论在生活方式干预基础上静脉滴注膦甲酸钠氯化钠注射液可降低高危型HPV持续感染患者宫颈灌洗液中IL-4水平,并可升高IL-12、IFN-γ水平。Objective To investigate the regulatory effect of foscarnet sodium on interleukin-4(IL-4),interleukin-12(IL-12)and interferon-γ(IFN-γ)in cervical lavage fluid of patients with persistent high-risk human papillomavirus(HPV)infection.Methods Sixty patients with persistent high-risk HPV infection in Changshu Fifth People's Hospital from October 2015 to December 2016 were selected.The 60 patients were randomly divided into lifestyle intervention group and foscarnet sodium treatment group,with 30 cases in each group.And 30 healthy persons who underwent physical examination during the same period were selected as normal control group.The lifestyle intervention group was given reasonable exercise,sleep assurance and condom use in sexual life,and the sodium foscarnet group was given intravenous drip of sodium foscarnet and sodium chloride injection for 2 weeks on the basis of the treatment in the lifestyle intervention group,both groups were intervened for 3 months.The levels of IL-4,IL-12 and IFN-γin cervical lavage fluid of all subjects were measured by ELISA before and after treatment.Results Before treatment,the levels of IL-4 in cervical lavage fluid of patients in lifestyle intervention group and foscarnet sodium treatment group were higher than those of normal control group(P all<0.01),the levels of IL-12 and IFN-γwere lower than those of the control group(P all<0.01).There was no significant difference in the levels of IL-4,IL-12 or IFN-γin cervical lavage fluid before and after treatment in lifestyle intervention group(P>0.05).The levels of IL-4 in cervical lavage fluid of patients in foscarnet sodium treatment group were lower than those before treatment(P<0.01),while the levels of IL-12 and IFN-γwere higher(P<0.01).Conclusions On the basis of lifestyle intervention,intravenous drip of foscarnet sodium and sodium chloride injection can reduce the level of IL-4 in cervical lavage fluid and increase the levels of IL-12 and IFN-gamma in patients with persistent high-risk HPV infection.

关 键 词：膦甲酸钠 高危型人乳头瘤病毒持续感染 白细胞介素-4 白细胞介素-12 干扰素-Γ 

分 类 号：R737.33[医药卫生—肿瘤]