局部晚期宫颈癌放疗同期洛铂化疗疗效分析  

Clinical Efficacy of Radiotherapy Combined With Lobaplatin Chemotherapy in the Treatment of Locally Advanced Cervical Cancer

作　　者：周亚燕[1] 李子煌[1] 龚龙[1] 闫茂生[1] 李先明[1] ZHOU Yayan;LI Zihuang;GONG Long;YAN Maosheng;LI Xianming(Department of Radiation Oncology,The Second Clinical Medical College of Ji’nan University/Shenzhen People's Hospital,Shenzhen Guangdong 518000,China)

机构地区：[1]暨南大学第二临床医学院/深圳市人民医院肿瘤放疗科,广东深圳518000

出　　处：《中国继续医学教育》2019年第13期124-126,共3页China Continuing Medical Education

基　　金：深圳市卫生计生系统科研项目(SZFZ2018018)

摘　　要：目的探析局部晚期宫颈癌患者采用放射治疗同期联合洛铂化疗的近期疗效及安全性。方法选取本院2013年1月—2015年12月接收的90例局部晚期宫颈癌患者,根据治疗方式的不同将其分为观察组与对照组,每组45例,观察组接受放疗同期联合洛铂化疗、对照组接受放疗同期联合顺铂化疗。对比近期疗效以及不良反应发生情况。结果观察组治疗近期总有效率与对照组比较差异无统计学意义(P>0.05)。观察组骨髓抑制发生率高于对照组且其胃肠道反应低于对照组(P <0.05);两组肝肾功能损伤和放射性直肠炎对比差异无统计学意义(P> 0.05)。结论局部晚期宫颈癌患者接受放疗的同时加以洛铂同期化疗临床疗效肯定,并能够降低患者的不良反应。Objective To investigate the short-term efficacy and safety of concurrent radiotherapy combined with lobaplatin chemotherapy in patients with locally advanced cervical cancer.Methods 90 cases of patients with locally advanced cervical cancer received from January 2013 to December 2015 were divided into observation group and control group according to different treatment methods,45 cases in each group.The observation group was received radiotherapy,in the same period,combined with lobaplatin chemotherapy,the control group was received radiotherapy combined with cisplatin chemotherapy.The short-term efficacy and the occurrence of adverse reactions and quality of life scores were compared.Results There was no significant difference in the short-term total effective rate between the observation group and the control group(P>0.05).The incidence of bone marrow suppression in the observation group was higher than that in the control group,and the gastrointestinal reaction in the observation group was lower than that in the control group(P<0.05).There was no significant difference in liver and kidney function damage and radiation proctitis between the two groups(P>0.05).Conclusion Patients with locally advanced cervical cancer receive radiotherapy and have a positive clinical effect with concurrent platinum-platinum chemotherapy,and can reduce the adverse reactions of patients.

关 键 词：局部晚期宫颈癌 化疗 放疗 顺铂 洛铂 骨髓抑制 

分 类 号：R737[医药卫生—肿瘤]