Nickel(II)-Catalyzed Diastereo- and Enantioselective [3+2] Cycloaddition of a-Ketoesters with 2-Nitrovinylindoles and 2-Nitrovinylpyrroles  

作　　者：Wu-Lin Yang Zhong-Tao Sun Hao Sun Wei-Ping Deng 

机构地区：[1]Shanghai Key Laboratory of New Drug Design and School of Pharmacy,East China University of Science and Technology,130 Meilong Road,Shanghai 200237,China

出　　处：《Chinese Journal of Chemistry》2019年第3期216-220,共5页中国化学（英文版）

摘　　要：Summary of main observation and conclusion The catalytic asymmetric [3+2] cycloaddition of a-ketoesters w让h 2-nitrovinylindoles and 2-nitrovinylpyrroles has been established. This strategy allowed the construction of structurally diverse pyrrolo[l,2-a]indoles bearing three contiguous stereocenters in generally high yields and good to excellent stereoselectivities (up to 98% yield,>98:2 dr, 99% ee). The efficient synthesis of tetracyclic psychotropic compound analogue via the derivatization of cycloadduct showed the great synthetic potential of this strategy.

关 键 词：CATALYTIC ASYMMETRIC ENANTIOSELECTIVE 

分 类 号：O6[理学—化学]