人群TP53基因Arg72Pro位点多态性与甲状腺癌发病风险相关性的meta分析  

Meta-analysis for the association between TP53 Arg72Pro polymorphism and human thyroid cancer risk

作　　者：武亚运 王勇攀[1] 顾海青[1] 王全[1] 黄伟强[1] 董晓强[2] Wu Yayun;Wang Yongpan;Gu Haiqing;Wang Quan;Huang Weiqiang;Dong Xiaoqiang(Department of General Surgery,the First People′s Hospital of Jiashan,Zhejiang Province,Jiashan 314100,China;Department of General Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]浙江省嘉善县第一人民医院普外科,314100 [2]苏州大学附属第一医院普外科,215006

出　　处：《中华内分泌代谢杂志》2019年第4期289-295,共7页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的探讨人群TP53基因Arg72Pro(rs1042522)位点单核苷酸多态性与甲状腺癌的相关性。方法检索PubMed、Embase、Web of Science数据库,搜索TP53基因Arg72Pro位点多态性与甲状腺癌发病风险相关的文献,筛选出符合要求的风险关联性研究,使用Stata 14.0软件进行meta分析,并进行敏感性分析、亚组分析及发表偏倚评价。采用比值比(OR)及其相应的95%CI作为效应量来评价TP53基因Arg72Pro位点单核苷酸多态性与甲状腺癌发病风险的关系。结果共计13篇文献纳入meta分析,甲状腺癌2 112例,对照4 000例。Meta分析的总体结果显示,TP53基因Arg72Pro位点的突变纯合子(Pro/Pro)基因型能够增加总人群罹患甲状腺癌的风险(隐性模型OR=1.78,95% CI 1.24~2.56,P=0.002),在甲状腺癌患者中该位点Pro突变比例较高(等位基因模型OR=1.35,95% CI 1.12~1.63,P=0.002)。亚组分析显示,该位点的突变纯合子(Pro/Pro)基因型能够增加亚洲人罹患甲状腺癌的风险,但与欧洲人及南美洲人罹患甲状腺癌无关;该位点的突变纯合子(Pro/Pro)基因型能够增加总人群罹患甲状腺乳头状癌的风险,但与总人群罹患甲状腺髓样癌无关。结论TP53基因Arg72Pro位点突变与甲状腺癌的发生相关,尤其在亚洲人群中,该位点的突变纯合子基因型Pro/Pro可能为甲状腺癌发生的危险因素。Objective To explore the association of single nucleotide polymorphism (SNP) in TP53 Arg72Pro (rs1042522) locus with thyroid cancer risk in human. Methods Articles involved in the association between SNP in TP53 Arg72Pro (rs1042522) locus and thyroid cancer risk were retrieved from PubMed, Embase, and Web of Science databases, and studies which met the inclusion criteria were included. The meta-analysis, sensitivity analysis, subgroup analysis, and the assessment of publication-bias were performed by Stata 14.0 software. The odds ratio (OR) and their corresponding 95% Confidence Intervals (CI) were used to determine the strength of association between SNP in TP53 Arg72Pro locus and thyroid cancer risk. Results Thirteen case-control studies were eligible for this meta-analysis, including 2 112 thyroid cancer cases and 4 000 control subjects. Overall, mutated homozygous genotype (Pro/Pro) in TP53 Arg72Pro(rs1042522) locus was associated with significantly increased thyroid cancer risk(Recessive model, OR=1.78, 95% CI 1.24-2.56, P=0.002), showing a significantly higher Pro mutation frequency among thyroid cancer patients (Allelic model, OR=1.35, 95% CI 1.12-1.63, P=0.002). In the stratified analysis, mutated homozygous genotype (Pro/Pro) in TP53 Arg72Pro (rs1042522) locus was only asscociated with significantly increased thyroid cancer risk among Asians, but not among Europeans and South Americans;mutated homozygous genotype (Pro/Pro) in TP53 Arg72Pro (rs1042522) locus was asscociated with significantly increased risk of papillary thyroid carcinomas among total population, but not medullary thyroid carcinomas. Conclusion There is a significant association between Arg72Pro polymorphism in TP53 gene and thyroid cancer risk, and the mutated homozygous genotype (Pro/Pro) in this locus of TP53 maybe a risk factor for thyroid carcinoma among Asians.

关 键 词：甲状腺癌 Arg72Pro TP53 基因多态性 META分析 

分 类 号：R736.1[医药卫生—肿瘤]